{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:58:34Z","timestamp":1790085514314,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T00:00:00Z","timestamp":1654387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dual kidney transplantation (DKT), utilizing two adult kidneys from the same donor for one recipient, has been used as a way to expand the available donor pool. These kidneys often come from high Kidney Donor Profile Index donors (KDPI\u00a0&gt;\u00a085%). Data comparing outcomes between high KDPI DKT and single kidney transplants (SKT) remain limited. We assessed outcomes of 336 high KDPI kidney transplants performed at our center; 11.0% (n\u00a0=\u00a037) were DKT. Recipients of DKT were older (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) and donors had a higher KDPI score (median 96%\u00a0vs. 91%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). DKT operative time was higher compared to SKT (+1.4\u00a0hours, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). There were no differences in delayed graft function (54.1%\u00a0vs. 51.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.77) and hospital length of stay (median 4.0\u00a0vs. 3.0 days, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.21) between DKT and SKT. Grade I Clavien\u2010Dindo complications occurred in 8.1% of DKT and 13.7% of SKT (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008). There were no grade IVa, IVb, or V complications in either group. DKT had more glomerulosclerosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04), interstitial fibrosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), tubular atrophy (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), and arterial thickening (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) on 1\u2010year protocol biopsies. Estimated glomerular filtration was higher for DKT at 1\u2010 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) and 2\u2010years post\u2010transplant (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). There were no differences in patient (HR 1.3, 95% CI .5\u20103.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.58) or graft (HR 1.1, 95% CI .5\u20102.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.83) survival. Good outcomes can be achieved with DKT using high KDPI kidneys with moderate chronic changes. DKT is a good option to help further utilize high KDPI kidneys and minimize discard.<\/jats:p>","DOI":"10.1111\/ctr.14737","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T15:55:07Z","timestamp":1653753307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Outcomes of dual kidney transplants from high KDPI kidneys are superior compared to single kidney high KDPI transplants at 1 year"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0959-5656","authenticated-orcid":false,"given":"Devika","family":"Das","sequence":"first","affiliation":[{"name":"Division of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-3290","authenticated-orcid":false,"given":"Josiah","family":"Wagler","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3981-4867","authenticated-orcid":false,"given":"Stephanie","family":"Ohara","sequence":"additional","affiliation":[{"name":"Division of Surgery Valleywise Health Medical Center Creighton University  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4827-6367","authenticated-orcid":false,"given":"Michelle","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6765-1797","authenticated-orcid":false,"given":"Peter E.","family":"Frasco","sequence":"additional","affiliation":[{"name":"Division of Anesthesiology Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9485-4036","authenticated-orcid":false,"given":"Maxwell","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-1727","authenticated-orcid":false,"given":"Hasan","family":"Khamash","sequence":"additional","affiliation":[{"name":"Division of Nephrology Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-2014","authenticated-orcid":false,"given":"Amit K.","family":"Mathur","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-4452","authenticated-orcid":false,"given":"Pooja","family":"Budhiraja","sequence":"additional","affiliation":[{"name":"Division of Nephrology Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8912-2108","authenticated-orcid":false,"given":"Kunam","family":"Reddy","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0367-2008","authenticated-orcid":false,"given":"Raymond","family":"Heilman","sequence":"additional","affiliation":[{"name":"Division of Nephrology Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-9519","authenticated-orcid":false,"given":"Caroline","family":"Jadlowiec","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"HartA OPTN\/SRTR 2019 Annual Data Report: Kidney. 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