{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:51:14Z","timestamp":1784310674117,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recipient functional status prior to transplantation can significantly impact post\u2010transplant survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The United Network for Organ Sharing database was queried for adult heart transplants including data on functional capacity and from February 1, 2005 to March 1, 2021; there were 32\u00a0875 cases included. The four functional categories studied were based on adult daily activities of living and were separated into total assistance required, some assistance required, no assistance required, and near death. Survival outcomes were compared for recipient's pretransplant level of functional status versus those with near death status. These were compared using adjusted logistic regression (odds of death at 30 days and 1 year) and conditional Cox models (overall survival and time until post\u2010transplant rejection). All models were adjusted for donor age, sex, ethnicity, ischemic time, as well as recipient age, sex, ethnicity, length of stay, UNOS region, ventricular assist device, creatinine, days on the waiting list, and status at transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 12\u00a0953 recipients classified as \u201cnear death\u201d or \u201cseverely disabled\u201d; 7711 \u201crequired total assistance in daily living\u201d, 7,328 \u201cneeded some\u201d, and 4883 \u201cneeded none\u201d. In adjusted models, the probabilities of death for the lowest functioning groups within 30 days and 1 year were 5% and 10%, respectively. Those \u201crequiring total assistance\u201d had analogous probabilities of 3% (OR\u00a0=\u00a00.58; <jats:italic>p<\/jats:italic> &lt;\u00a00.001) and 9% (OR\u00a0=\u00a00.81; <jats:italic>p<\/jats:italic> &lt;\u00a00.001). Those \u201crequiring some assistance\u201d had probabilities of 3% (OR\u00a0=\u00a00.56; <jats:italic>p<\/jats:italic> &lt;\u00a00.001) and 9% (OR\u00a0=\u00a00.74; <jats:italic>p<\/jats:italic> &lt;\u00a00.001). Lastly, those \u201crequiring no assistance\u201d had probabilities of death of 2% (OR\u00a0=\u00a00.35; <jats:italic>p<\/jats:italic> &lt;\u00a00.001) and 7% (OR\u00a0=\u00a00.63; <jats:italic>p<\/jats:italic> &lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recipient functional status assessed pre\u2010transplant and recorded in the UNOS database is a strong predictor of post\u2010transplant survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14748","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T15:30:27Z","timestamp":1655739027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Functional status of heart transplant recipients predicts survival"],"prefix":"10.1111","volume":"36","author":[{"given":"Taylor B.","family":"Shaw","sequence":"first","affiliation":[{"name":"Department of Surgery University of Mississippi Medical Center  Jackson Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3785-5470","authenticated-orcid":false,"given":"David","family":"Blitzer","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Cardiovascular Surgery Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen T.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Mississippi Medical Center  Jackson Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Lirette","sequence":"additional","affiliation":[{"name":"Fulcrum  Jackson Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Division of Advanced Heart Failure, Heart Transplant and Mechanical Circulatory Support Lutheran Hospital Fort Wayne  Fort Wayne Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Copeland","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7754-9953","authenticated-orcid":false,"given":"David A.","family":"Baran","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Heart Vascular and Thoracic Institute  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-5194","authenticated-orcid":false,"given":"Hannah","family":"Copeland","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Heart Transplant, Mechanical Circulatory Support and Extracorporeal Membrane Oxygenation (ECMO) Lutheran Hospital  Fort Wayne Indiana USA"},{"name":"Indiana University School of Medicine \u2010 Fort Wayne (IUSM\u2010FW)  Fort Wayne Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03343-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.858076"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.119.005795"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-199407000-00002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.09.038"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840501)53:9<2002::AID-CNCR2820530933>3.0.CO;2-W"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.025"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13483"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002397"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.05.080"},{"key":"e_1_2_10_12_1","first-page":"1600","article-title":"OPTN\/SRTR 2019 annual data report: heart","volume":"21","author":"Colvin M","year":"2020","journal-title":"Am J Transplant"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.4909"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4612-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201611-843SR"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00776-3"},{"issue":"2","key":"e_1_2_10_17_1","first-page":"130","article-title":"Early mobilization of LVAD recipients who require prolonged mechanical ventilation","volume":"33","author":"Perme C","year":"2006","journal-title":"Tex Heart Inst J"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.01.011"}],"container-title":["Clinical 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