{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:08:18Z","timestamp":1790377698247,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known about the effects of hepatitis C viremia on immunologic outcomes in the era of direct\u2010acting antivirals. We conducted a prospective, single\u2010arm trial of lung transplantation from hepatitis C\u2010infected donors into hepatitis C\u2010na\u00efve recipients (n\u00a0=\u00a021). Recipients were initiated on glecaprevir\u2010pibrentasvir immediately post\u2010transplant and were continued on therapy for a total of 8\u00a0weeks. A control group of recipients of hepatitis C\u2010negative lungs were matched 1:1 on baseline variables (n\u00a0=\u00a021). The primary outcome was the frequency of acute cellular rejection over 1\u2010year post\u2010transplant. Treatment with glecaprevir\u2010pibrentasvir was well tolerated and resulted in viremia clearance after a median of 16 days of therapy (IQR 10\u201324 days). At one year, there was no difference in incidence of acute cellular rejection (71.4%\u00a0vs. 85.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.17) or rejection requiring treatment (33.3%\u00a0vs. 57.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.12). Mean cumulative acute rejection scores were similar between groups (.46 [SD \u00b1 .53] vs. .52 [SD\u00a0\u00b1 .37], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.67). Receipt of HCV+ organs was not associated with acute rejection on unadjusted Cox regression analysis (HR .55, 95% CI .28\u20101.11, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.09), or when adjusted for risk factors known to be associated with acute rejection (HR .57, 95% CI .27\u20101.21, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.14). Utilization of hepatitis C infected lungs with immediate treatment leads to equivalent immunologic outcomes at 1 year.<\/jats:p>","DOI":"10.1111\/ctr.14749","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T16:25:13Z","timestamp":1654964713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["One\u2010year immunologic outcomes of lung transplantation utilizing hepatitis C\u2010viremic donors"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-1917","authenticated-orcid":false,"given":"Tyler C.","family":"Lewis","sequence":"first","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lesko","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darya","family":"Rudym","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie E.","family":"Lonze","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Mangiola","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake G.","family":"Natalini","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin C.Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie H.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Angel","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York 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