{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:02:58Z","timestamp":1787061778597,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post heart\u2010transplant survival has increased, but information is lacking on specific causes of death and life expectancy. We aimed to assess cause\u2010specific loss of life\u2010years compared to the general population, evaluate classification for cause of death after heart transplantation, and assess validity of cause of death data from the International Society of Heart and Lung Transplant (ISHLT) registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this single center study, we included 239 heart recipients transplanted between 1988 and 2019 in Lund, Sweden (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0239, 50% of the transplanted population where the cause of death was available). Two cardiologists retrospectively assigned causes of death according to a published classification (CLASS) in the 91 recipients who died during follow\u2010up. Life expectancy was compared to data from the general population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to the average Swedish population, life expectancy for heart transplant recipients was 20 years shorter (IQR 12.9\u201327.2). The largest number of life\u2010years lost were for deaths due to acute (49 years) and chronic rejection (27 years). Primary graft dysfunction (24 years) accounted for 24% of deaths, followed by malignancy (20 years) and infection (17 years), each accounting for \u223c20% of deaths. Use of CLASS revealed moderate inter\u2010rater agreement (56%) and moderate agreement with the ISHLT registry (62%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Survival after heart transplantation was 20 years lower than in the general population. In the young, more life\u2010years were lost due to acute graft rejection, whereas chronic graft rejection and primary graft failure were more important causes of death in older patients. Agreement was moderate between CLASS and the ISHLT registry classifications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.14756","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T01:24:01Z","timestamp":1655774641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Validation of cause of death classification after heart transplantation and cause\u2010specific life expectancy compared to the general population"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-6689","authenticated-orcid":false,"given":"Grunde","family":"Gjesdal","sequence":"first","affiliation":[{"name":"Department of Cardiology Clinical Sciences Lund University  Lund Sweden"},{"name":"Section for Heart Failure and Valvular Disease, Department of Heart and Lung Medicine Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinical Sciences Lund University  Lund Sweden"},{"name":"Section for Heart Failure and Valvular Disease, Department of Heart and Lung Medicine Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Czuba","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinical Sciences Lund University  Lund Sweden"},{"name":"The Wallenberg Laboratory, Department of Molecular and Clinical Medicine Institute of Medicine Gothenburg University and the Department of Cardiology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neval Ete","family":"Wareham","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Health, Immunity and Infections Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6860-6090","authenticated-orcid":false,"given":"Johan","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Cardiothoracic surgery and bioinformatics Lund University and Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Gustav","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinical Sciences Lund University  Lund Sweden"},{"name":"Section for Heart Failure and Valvular Disease, Department of Heart and Lung Medicine Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"The Wallenberg Laboratory, Department of Molecular and Clinical Medicine Institute of Medicine Gothenburg University and the Department of Cardiology Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Wallenberg Center for Molecular Medicine and Lund University Diabetes Center Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar \u00d6.","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinical Sciences Lund University  Lund Sweden"},{"name":"Section for Heart Failure and Valvular Disease, Department of Heart and Lung Medicine Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029753"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.08.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs160"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.12.186"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-009-9383-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.08.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.01.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011564"},{"key":"e_1_2_10_10_1","unstructured":"www.scb.se(Accessed 2021\u201012\u201010)"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705727"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1070"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13584\u2010015\u20100047\u20102"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03400030065033"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym003"},{"key":"e_1_2_10_16_1","first-page":"355","article-title":"Pretransplantation risk factors for acute rejection after heart transplantation: a multiinstitutional study. The Transplant Cardiologists Research Database Group","volume":"12","author":"Kobashigawa JA","year":"1993","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2010.11.023"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.08.008"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.14756","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T16:14:20Z","timestamp":1692720860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.14756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,28]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/ctr.14756"],"URL":"https:\/\/doi.org\/10.1111\/ctr.14756","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,28]]},"assertion":[{"value":"2021-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14756"}}