{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T14:46:28Z","timestamp":1760453188800,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neutropenia post\u2010kidney transplantation is associated with adverse graft and patient outcomes. We aimed to analyze the effect of granulocyte colony\u2010stimulating factor (G\u2010CSF) use with and without immunosuppression reduction on graft outcomes in neutropenic recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective cohort study, we identified 120 recipients with neutropenia, within the first\u2010year post\u2010transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of these, 45.0% underwent no intervention, 17.5% had immunosuppression reduced, 18.3% were only given G\u2010CSF, and 19.2% had both interventions. Overall, 61 patients experienced the composite outcome of de\u2010novo DSA, biopsy\u2010proven acute rejection, and all\u2010cause graft failure and the cumulative incidence of this outcome did not vary by any of the four interventions (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.93). When stratifying the cohort by G\u2010CSF use alone, those who received G\u2010CSF were more likely to have had severe neutropenia (&lt;500\/mm<jats:sup>3<\/jats:sup>: 51.1% vs. 12.0%,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and immunosuppression reduction (51.1%\u00a0vs. 28.0%,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003). However, the composite outcome was not different in the G\u2010CSF and no G\u2010CSF cohort (53.3%\u00a0vs. 49.3%,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.67), and in a multivariate model, G\u2010CSF use was not associated with this outcome (aHR\u00a0=\u00a01.18, 95% CI: .61\u20132.30). However, a trend towards higher DSA production was noted in the G\u2010CSF cohort (87.5%\u00a0vs. 62.2%) and this observation warrants prospective evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, we conclude that G\u2010CSF use with or without immunosuppression reduction was not associated with graft outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14766","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T07:39:40Z","timestamp":1657697980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Granulocyte colony\u2010stimulating factor with or without immunosuppression reduction in neutropenic kidney transplant recipients"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-0598","authenticated-orcid":false,"given":"Shaifali","family":"Sandal","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Medicine McGill University Health Centre Montreal Quebec Canada"},{"name":"MeDIC department Research Institute of the McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Yao","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahsan","family":"Alam","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine McGill University Health Centre Montreal Quebec Canada"},{"name":"MeDIC department Research Institute of the McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D\u2019","family":"Arienzo","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Baran","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine McGill University Health Centre Montreal Quebec Canada"},{"name":"MeDIC department Research Institute of the McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Cantarovich","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine McGill University Health Centre Montreal Quebec Canada"},{"name":"MeDIC department Research Institute of the McGill University Health Centre Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02699.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200002270-00011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl539"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31821c1e70"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13058"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1111\/petr.14131","article-title":"Characteristics, risk factors, and outcomes of neutropenia after liver or kidney transplantation in children","volume":"26","author":"Jarasvaraparn C","year":"2021","journal-title":"Pediatr 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