{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:47:05Z","timestamp":1780523225092,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data are limited on outcomes after heart transplantation in patients bridged\u2010to\u2010transplantation (BTT) with a total artificial heart (TAH\u2010t).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The UNOS database was used to identify 392 adult patients undergoing heart transplantation after TAH\u2010t BTT between 2005 and 2020. They were compared with 11\u00a0014 durable left ventricular assist device (LVAD) BTT patients and 22\u00a0348 de novo heart transplants (without any durable VAD or TAH\u2010t BTT) during the same period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TAH\u2010t BTT patients had increased dialysis dependence compared to LVAD BTT and de novo transplants (24.7%\u00a0vs. 2.7%\u00a0vs. 3.8%) and higher levels of baseline creatinine and total bilirubin (all <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001). After transplantation, TAH\u2010t BTT patients were more likely to die from multiorgan failure in the first year (25.0%\u00a0vs. 16.1%\u00a0vs. 16.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). Ten\u2010year survival was inferior in TAH\u2010t BTT patients (TAH\u2010t BTT 53.1%, LVAD BTT 61.8%, De Novo 62.6%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), while 10\u2010year survival conditional on 1\u2010year survival was similar (TAH\u2010t BTT 66.8%, LVAD BTT 68.7%, De Novo 69.0%, all <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.20). Among TAH\u2010t BTT patients, predictors of 1\u2010year mortality included higher baseline creatinine and total bilirubin, mechanical ventilation, and cumulative center volume &lt;20 cases of heart transplantation involving TAH\u2010t BTT (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Survival after TAH\u2010t BTT is acceptable, and patients who survive the early postoperative phase experience similar hazards of mortality over time compared to de novo transplant patients and durable LVAD BTT patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14781","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T05:09:53Z","timestamp":1658120993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Heart transplantation after total artificial heart bridging\u2014Outcomes over 15 years"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2475-4312","authenticated-orcid":false,"given":"Qiudong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Smidt Heart Institute Cedars Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-561X","authenticated-orcid":false,"given":"Joshua","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Smidt Heart Institute Cedars Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4054-4550","authenticated-orcid":false,"given":"Akbarshakh","family":"Akhmerov","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Smidt Heart Institute Cedars Sinai Medical Center  Los Angeles California 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