{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:23:47Z","timestamp":1791937427757,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>There are several cPRA websites based on large enough samples in Eurotransplant, the United Network for Organ Sharing (UNOS), and the Canadian Transplant Registry (CTR). On the other hand, those calculators can differ based on the ethnicity to which they are applied. We developed the Iranian PRA calculator and compared it with UNOS and CTR calculators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The allele and haplotype frequencies of the Iranian donor pool were estimated using the HLA typing of 523 deceased Iranian kidney donors. The Organ Procurement and Transplantation Network formula was used to generate cPRA (cPRA frequency). We also used a computer script to compare the undesirable antigens of patients with the human leukocyte antigen (HLA) phenotype of donors (cPRA filtering). A total of 100 anti\u2010HLA antibody profiles were determined in 100 sensitized individuals on the waiting list, and cPRA was estimated using various PRA calculators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Variable allelic frequencies were obtained from population heterogeneity in each calculator's donor panel. However, no significant changes in cPRA were identified between the Iranian calculator, UNOS, and the Canadian online calculators. Lin's concordance correlation coefficient of .98 showed that cPRA (freq) and cPRA (filter) values had almost perfect agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation and Conclusion<\/jats:title><jats:p>The cPRA values from the Iranian calculator are comparable to those from UNOS and CTR calculators. The donor filtering method was more useful because of factors like cost and flexibility. It also makes it easier to update cPRA on a regular basis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14789","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T08:09:32Z","timestamp":1659859772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Iranian panel reactive antibody calculator and potential usefulness: A retrospective study"],"prefix":"10.1111","volume":"36","author":[{"given":"Sahand","family":"Mohammadzadeh","sequence":"first","affiliation":[{"name":"Shiraz Transplant Center Abu\u2010Ali Sina Hospital Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Reza","family":"Jaladat","sequence":"additional","affiliation":[{"name":"Shiraz Transplant Center Abu\u2010Ali Sina Hospital Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Faculty of Electrical and Computer Engineering Shiraz University  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Geramizadeh","sequence":"additional","affiliation":[{"name":"Shiraz Transplant Center Abu\u2010Ali Sina Hospital Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2317-0737","authenticated-orcid":false,"given":"Mohammad Hossein","family":"Anbardar","sequence":"additional","affiliation":[{"name":"Shiraz Transplant Center Abu\u2010Ali Sina Hospital Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Soleimani","sequence":"additional","affiliation":[{"name":"Shiraz Transplant Center Abu\u2010Ali Sina Hospital Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elahe","family":"Amirinezhad Fard","sequence":"additional","affiliation":[{"name":"Medical Biology Research Center Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges Jamshidian","family":"Tehrani","sequence":"additional","affiliation":[{"name":"Shiraz Transplant Center Abu\u2010Ali Sina Hospital Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196904032801401"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000129260.86766.67"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2013.08.007"},{"issue":"2","key":"e_1_2_8_5_1","first-page":"20","article-title":"Virtual crossmatching in kidney transplantation, Shiraz experience in development of a web\u2010based program","volume":"12","author":"Tehrani NJ","year":"2021","journal-title":"Int J Organ Transplant Med"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","unstructured":"KaradenizST AkgulSU OgretY et al.Corrected panel\u2010reactive antibody positivity rates for hypersensitized patients in Turkish population with calculated panel\u2010reactive antibody software. InTransplantation Proceedings 2017 Apr 1 (Vol. 49 No. 3 pp. 445\u2010447). Elsevier.","DOI":"10.1016\/j.transproceed.2017.01.032"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2012.01853.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.04.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198503000-00024"},{"key":"e_1_2_8_10_1","unstructured":"ProcurementO NetworkT US Department of Health and Human Services. 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