{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:19Z","timestamp":1753878619515,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alcohol\u2010associated liver disease (ALD) is a rising indication for liver transplantation (LT). Prolonged opioid use after LT leads to increased graft loss and mortality. The aim is to determine if patients transplanted with a primary diagnosis of ALD had higher risk of post\u2010LT opioid use (p\u2010LTOU) compared to non\u2010ALD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study of patients who underwent LT between 2015 and 2018 at Medstar Georgetown Transplant Institute. Patients with prolonged hospitalization post\u2010LT (&gt;90 days), death within 90 days post\u2010LT, and re\u2010transplants were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and ninety seven patients were transplanted, among 29% for indications of ALD. ALD patients were younger (52 vs. 56 years), more likely to be male (76% vs. 61%), Caucasian (71% vs. 44%), have higher MELD (28.8\u00b18.8 vs. 25\u00b18.8), and psychiatric disease than non\u2010ALD patients (<jats:italic>P<\/jats:italic> &lt; .05). There was no difference in pre\u2010LT use of opioids, tobacco, marijuana, or illicit drugs between ALD and non\u2010ALD patients. Pre\u2010LT opioid use (OR = 11.7, <jats:italic>P<\/jats:italic> &lt; .001), ALD (OR = 2.5, <jats:italic>P<\/jats:italic> = .01), and MELD score (OR = .95, <jats:italic>P<\/jats:italic> = .02) independently predicted 90\u2010day p\u2010LTOU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ALD, pre\u2010LT opioid use, and MELD score independently predict p\u2010LTOU. Special attention should be paid to identify post\u2010LT prolonged opioid use in ALD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14811","type":"journal-article","created":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T11:33:17Z","timestamp":1662291197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Alcohol\u2010associated liver disease predicts increased post\u2010liver transplant opioid use"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3303-4632","authenticated-orcid":false,"given":"Krystina A.","family":"Johnson\u2010Laghi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie M.","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaeema","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Fernandez","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Desale","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne E.","family":"Robertazzi","sequence":"additional","affiliation":[{"name":"MedStar Georgetown Transplant Institute Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coleman I.","family":"Smith","sequence":"additional","affiliation":[{"name":"MedStar Georgetown Transplant Institute Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arul M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"MedStar Georgetown Transplant Institute Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander T.","family":"Lalos","sequence":"additional","affiliation":[{"name":"MedStar Georgetown Transplant Institute Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Georgia","sequence":"additional","affiliation":[{"name":"MedStar Georgetown Transplant Institute Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle L.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"MedStar Georgetown Transplant Institute Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W.","family":"Faust","sequence":"additional","affiliation":[{"name":"MedStar Georgetown Transplant Institute Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Fishbein","sequence":"additional","affiliation":[{"name":"MedStar Georgetown Transplant Institute Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit S.","family":"Satoskar","sequence":"additional","affiliation":[{"name":"MedStar Georgetown Transplant Institute Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amol S.","family":"Rangnekar","sequence":"additional","affiliation":[{"name":"MedStar Georgetown Transplant Institute Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine C.","family":"Hsu","sequence":"additional","affiliation":[{"name":"MedStar Georgetown Transplant Institute Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1508490"},{"key":"e_1_2_9_3_1","unstructured":"Multiple\u2010Cause\u2010of\u2010Death file 2000\u20132014.CDC Wide\u2010ranging Online Data for Epidemiologic Research (WONDER). 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