{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:39:24Z","timestamp":1791261564191,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Significant weight loss due to cardiac cachexia is an independent predictor of mortality in many heart failure (HF) clinical trials. The impact of significant weight loss while on the waitlist for heart transplant (HT) has yet to be studied with respect to post\u2010transplant survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult HT recipients from 2010 to 2021 were identified in the UNOS registry. Patients who experienced an absolute weight change from the time of listing to transplant were included and classified into two groups by percent weight loss from time of listing to time of transplant using a cut\u2010off of 10%. The primary endpoint was 1\u2010year survival following HT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>5951 patients were included in the analysis, of whom 763 (13%) experienced \u226510% weight loss from the time of listing to transplant. Weight loss\u00a0\u2265\u00a010% was associated with reduced 1\u2010year post\u2010transplant survival (86.9%\u00a0vs. 91.0%, long\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0003). Additionally, weight loss\u00a0\u2265\u00a010% was an independent predictor of 1\u2010year mortality in a multivariable model adjusting for significant risk factors (adjusted HR 1.23, 95% CI 1.04\u20131.46). In secondary analyses, weight loss\u00a0\u2265\u00a010% was associated with reduced 1\u2010year survival independent of hospitalized status at time of transplant as well as obesity status at listing (i.e., body mass index [BMI]\u00a0&lt;\u00a030\u00a0kg\/m<jats:sup>2<\/jats:sup> and BMI\u00a0\u2265\u00a030\u00a0kg\/m<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative weight loss\u00a0\u2265\u00a010% is associated with reduced survival in patients listed for HT. Nutrition interventions prior to transplant may prove beneficial in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14831","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T14:53:16Z","timestamp":1666450396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of pre\u2010transplant weight loss on survival following cardiac transplantation"],"prefix":"10.1111","volume":"36","author":[{"given":"Elissa","family":"Driggin","sequence":"first","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Chung","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Concha","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Stanton","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veli K.","family":"Topkara","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew S.","family":"Maurer","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin A.","family":"Fried","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhana","family":"Latif","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Takeda","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Sayer","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Uriel","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Clerkin","sequence":"additional","affiliation":[{"name":"NewYork\u2010Presbyterian Hospital\/Columbia University Irving Medical Center, Division of Cardiology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.10.023"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13621"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.01.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.51"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12892-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn420"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.240"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13619"},{"key":"e_1_2_9_11_1","article-title":"Weight changes in heart failure with preserved ejection fraction: findings from TOPCAT","author":"Ferreira JP","year":"2021","journal-title":"Clin Res Cardiol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2019.03.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-013-0153-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.33433"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-011-0038-2"}],"container-title":["Clinical 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