{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:51:58Z","timestamp":1772837518169,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Serum albumin is an indicator of overall health status, but it remains unclear how pre\u2010transplant hypoalbuminemia is associated with early post\u2010transplant outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included all adult kidney transplant recipients (KTRs) at our center from 01\/01\/2001\u201312\/31\/2017 with serum albumin measured within 30 days before transplantation. KTRs were grouped based on pretransplant albumin level normal (\u22654.0\u00a0g\/dL), mild (\u22653.5\u00a0\u2013\u00a0&lt;\u00a04.0g\/dL), moderate (\u22653.0\u00a0\u2013\u00a0&lt;\u00a03.5g\/dL), or severe hypoalbuminemia (&lt;3.0g\/dL). Outcomes of interest included: length of hospital stay (LOS), readmission within 30 days, delayed graft function(DGF), and re\u2010operation related to post\u2010transplant surgical complications. We also analyzed rejection, graft failure, and death within 6 months post\u2010transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2807 KTRs were included 43.6% had normal serum albumin, 35.3% mild, 16.6% moderate, and 4.5% severe hypoalbuminemia. Mild and moderate hypoalbuminemia were associated with a shorter LOS by 1.22 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and 0.80 days (<jats:italic>p<\/jats:italic> = 0.01), respectively, compared to normal albumin. Moderate (HR: 0.58; 95% CI: 0.37\u20100.91; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) and severe hypoalbuminemia (HR: 0.21; 95% CI: 0.07\u20130.68; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) were associated with significantly lower rates of acute rejection within 6 months post\u2010transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with pre\u2010transplant hypoalbuminemia have post\u2010transplant outcomes similar to those with normal serum albumin, but with a lower risk of acute rejection based on the degree of hypoalbuminemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14862","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T04:45:19Z","timestamp":1668573919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pre\u2010transplant hypoalbuminemia is not associated with worse short\u2010term outcomes among kidney transplant recipients"],"prefix":"10.1111","volume":"37","author":[{"given":"Isabel","family":"Breyer","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad C.","family":"Astor","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"},{"name":"Department of Population Health Sciences University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniruddha","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin 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Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-9727","authenticated-orcid":false,"given":"Margaret R.","family":"Jorgenson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Wisconsin Hospital and Clinics  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier A.","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7465","authenticated-orcid":false,"given":"Sandesh","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin 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