{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:31:14Z","timestamp":1789763474157,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The illicit drug toxicity (overdose) crisis has worsened across Canada; between 2016 and 2021, more than 28,000 individuals have died of drug toxicity. Organ donation from persons who experience drug toxicity death (DTD) has increased in recent years. This study examines whether survival after heart or bilateral\u2010lung transplantation differed by donor cause of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied transplant recipients in British Columbia who received heart (<jats:italic>N<\/jats:italic>\u00a0=\u00a0110) or bilateral\u2010lung (<jats:italic>N<\/jats:italic>\u00a0=\u00a0223) transplantation from deceased donors aged 12\u201370 years between 2013 and 2019. Transplant recipient survival was compared by donor cause of death from drug toxicity or other. Five\u2010year Kaplan\u2010Meier estimates of survival and 3\u2010year inverse probability treatment weighted Cox proportional hazards models were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DTD donors made up 36% (40\/110) of heart and 24% (54\/223) of bilateral\u2010lung transplantations. DTD donors were more likely to be young, white, and male. Unadjusted 5\u2010year recipient survival was similar by donor cause of death (heart: 87% for DTD and 86% for non\u2010DTD, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.75; bilateral\u2010 lung: 80% for DTD and 76% for non\u2010DTD, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.65). Adjusted risk of mortality at 3\u2010years post\u2010transplant was similar between recipients of DTD and non\u2010DTD donor heart (hazard ratio [HR]: .94, 95% confidence interval (CI): .22\u20134.07, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.938) and bilateral\u2010lung (HR: 1.06, 95% CI: .41\u20132.70, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.908).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recipient survival after heart or bilateral\u2010lung transplantation from DTD donors and non\u2010DTD donors was similar. Donation from DTD donors is safe and should be considered more broadly to increase organ donation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14866","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T17:53:50Z","timestamp":1670954030000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcomes following heart or bilateral\u2010lung transplantation from donors who died of drug toxicity in British Columbia, Canada"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6027-3631","authenticated-orcid":false,"given":"Max Wenheng","family":"Xie","sequence":"first","affiliation":[{"name":"British Columbia Centre for Disease Control  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1071-4950","authenticated-orcid":false,"given":"Sean Patrick","family":"Keenan","sequence":"additional","affiliation":[{"name":"British Columbia Transplant  Vancouver BC Canada"},{"name":"University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-3962","authenticated-orcid":false,"given":"Mustafa","family":"Toma","sequence":"additional","affiliation":[{"name":"Division of Cardiology St. Paul's Hospital  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-5217","authenticated-orcid":false,"given":"Robert Daniel","family":"Levy","sequence":"additional","affiliation":[{"name":"British Columbia Transplant  Vancouver BC Canada"},{"name":"University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-0031","authenticated-orcid":false,"given":"Amanda","family":"Slaunwhite","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control  Vancouver BC Canada"},{"name":"University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1648-5845","authenticated-orcid":false,"given":"Caren","family":"Rose","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control  Vancouver BC Canada"},{"name":"University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Opioid\u2010related Harms in Canada","author":"Public Health Agency of Canada"},{"key":"e_1_2_10_3_1","volume-title":"Understanding the Epidemic | Drug Overdose | CDC Injury Center","author":"Centers for Disease Control and Prevention"},{"key":"e_1_2_10_4_1","unstructured":"BC Coroners Service.Illicit Drug Toxicity Deaths in BC January 1 2012 \u2013 March 31 2022.2022. 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