{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:00:14Z","timestamp":1790200814719,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Liver transplantation (LT) is the choice of therapeutic option for end\u2010stage hepatic GSD patients; however, reports about the long\u2010term outcome of LT in these patients have remained controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic review and meta\u2010analysis of observational studies published until Dec 31, 2021, that investigated\u00a0the long\u2010term outcome of LT in hepatic GSD patients. A literature search in the MEDLINE\/PubMed, EMBASE,Cochrane Library, Scopus and Web of Science Core Collection databases was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      14 studies with 210 patients were included in our analysis. As the results showed, the pooled proportion of GSD patients with complications after liver transplant (e.g., hemorrhagic shock, biliary complications, tacrolimus encephalopathy, chronic hepatitis, hepatic artery thrombosis, hepatic adenoma, sepsis, liver dysfunction, chronic rejection, acute cellular rejection, and CMV infection) was 27.7% (95% CI: 20.42\u201335.67) without heterogeneity (\n                      <jats:italic>\n                        I\n                        <jats:sup>2<\/jats:sup>\n                      <\/jats:italic>\n                      \u00a0=\u00a024.04%), as calculated by the random\u2010effect model. The pooled proportion of GSD patients with complications related to GSD after LT, including HCC (Hepatocellular carcinoma), renal complication, muscle problems, delayed menarche, persistent neutropenia, pneumonitis, renal failure, and hepatic adenoma was 22.2% (95% CI: 7.97\u201340.01) with high heterogeneity (\n                      <jats:italic>\n                        I\n                        <jats:sup>2<\/jats:sup>\n                      <\/jats:italic>\n                      \u00a0=\u00a082.47%). Subgroup analysis including the age of patients (adult\/pediatric), duration of follow\u2010up, and type of donor was conducted to investigate the resources of heterogeneity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>According to our investigation and review analysis, most GSD patients showed significant outcome improvement after liver transplantation. Overall, our findings showed an excellent outcome of liver transplantation in GSD patients; however, it needs further investigations to be confirmed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.14867","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T09:30:12Z","timestamp":1669455012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcome of liver transplantation in hepatic glycogen storage disease: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"37","author":[{"given":"Zahra","family":"Beyzaei","sequence":"first","affiliation":[{"name":"Transplant Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Shiraz University of Medical Sciences  Shiraz 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