{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:53:39Z","timestamp":1765961619154,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although there are many studies on the role of vitamin D deficiency (VDD) in hematopoetic stem cell transplantation (HSCT), outcomes have often reported conflicting results because of the heterogeneity of the patients in the studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the association between VDD prior to HSCT and outcomes after HSCT in a relatively homogenous group of patients with thalassemia major (TM) who received identical treatment for TM before transplantation, and the same conditioning regimen and GVHD prophylaxis during and after transplantation. All patients, including the patients with normal vitamin D<jats:sub>3<\/jats:sub> levels received 400 to 800 IU per day of vitamin D for the first 6 months after HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pre\u2010HSCT VDD increased the frequency of aGVHD after transplantation, particularly in HSCTs performed with PBSC for the stem cell source. Pre\u2010transplant low vitamin D<jats:sub>3<\/jats:sub> levels had no association with transplant outcomes such as engraftment, viral infections, alloimmunization, chronic GvHD, total days of hospitalization, and success in terms of transfusion independence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low vitamin D<jats:sub>3<\/jats:sub> levels before HSCT carry a significant risk for aGVHD. All patients with TM should be screened for VDD before HSCT, and every effort should be made to supplement vitamin D before the transplant in VDD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14874","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T04:54:23Z","timestamp":1670043263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pre\u2010transplantation vitamin D deficiency increases acute graft\u2010versus\u2010host disease after hematopoietic stem cell transplantation in thalassemia major patients"],"prefix":"10.1111","volume":"37","author":[{"given":"Hayriye","family":"Dalo\u011flu","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences Department of Pediatric Bone Marrow Transplantation Unit MedicalPark Antalya Hospital Antalya Bilim University  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedat","family":"Uygun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Bone Marrow Transplantation Unit MedicalPark Antalya Hospital \u0130stinye University Faculty of Medicine  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"\u00d6zt\u00fcrkmen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Bone Marrow Transplantation Unit MedicalPark Antalya Hospital  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koray","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Pediatric Bone Marrow Transplantation Unit MedicalPark G\u00f6ztepe Hospital Bah\u00e7e\u015fehir University  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcls\u00fcn","family":"Karasu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Bone Marrow Transplantation Unit MedicalPark G\u00f6ztepe Hospital  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akif","family":"Ye\u015filipek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Bone Marrow Transplantation Unit MedicalPark Antalya Hospital  Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10405"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.102350"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10050987"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26817"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0377-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704448"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.177"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20140029"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-021-05821-w"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.12.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.06.015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.09.004"},{"issue":"6","key":"e_1_2_8_15_1","first-page":"825","article-title":"1994 consensus conference on acute GVHD grading [Consensus Development Conference Review]","volume":"15","author":"Przepiorka D","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13546"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28190"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.05.030"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12383"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2013.057"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-01031-w"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.43"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111465"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(86)90291-1"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.14874","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.14874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T12:55:58Z","timestamp":1692449758000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.14874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/ctr.14874"],"URL":"https:\/\/doi.org\/10.1111\/ctr.14874","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2022,12,14]]},"assertion":[{"value":"2022-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14874"}}