{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:05:28Z","timestamp":1776974728170,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The increased procurement of organs from donors with risk factors for blood\u2010borne diseases and the expanding syphilis epidemic have resulted in a growing number of organs transplanted from donors with reactive syphilis serology in our center. Based on guidelines, recipients typically receive therapy shortly after the transplant, but data on outcomes are limited. The primary objective of this study was to determine syphilis seroconversion rates at three months post\u2010transplant in recipients of solid organs procured from donors with reactive syphilis serology. Organ donors and recipients were tested for syphilis antibody; positive results were confirmed with Treponema pallidum Particle Agglutination (TPPA). Eleven donors with reactive syphilis antibody donated organs to 25 syphilis negative recipients. Three recipients seroconverted at post\u2010transplant month 3. All of them had received therapy shortly after transplant. TPPA was negative in all 3. Despite post\u2010transplant treatment, 3 of 25 (12%) syphilis negative recipients of organs from syphilis positive donors seroconverted at 3 months. All remained TPPA negative possibly reflecting passive antibody transfer or differing test sensitivity to low level treponemal antibodies. Further studies are needed to assess optimal syphilis transmission prevention strategies and follow up recipient testing in organ transplantation.<\/jats:p>","DOI":"10.1111\/ctr.14896","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T11:22:57Z","timestamp":1672399377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serologic follow\u2010up of solid organ transplant recipients who received organs from donors with reactive syphilis tests: A retrospective cohort study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-3756","authenticated-orcid":false,"given":"Oscar A.","family":"Fern\u00e1ndez Garc\u00eda","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-3704","authenticated-orcid":false,"given":"Ameeta E.","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6999-9201","authenticated-orcid":false,"given":"Jennifer","family":"Gratrix","sequence":"additional","affiliation":[{"name":"Centralized STI Services Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-4933","authenticated-orcid":false,"given":"Petra","family":"Smyczek","sequence":"additional","affiliation":[{"name":"Centralized STI Services Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1660-9166","authenticated-orcid":false,"given":"Karen","family":"Doucette","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001648"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001341"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa056"},{"key":"e_1_2_8_5_1","unstructured":"Canadian Centre on Substance use and Addiction. 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