{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T09:29:37Z","timestamp":1758274177948,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our previous Multicenter Trial to Transplant HCV\u2010infected Kidneys (MYTHIC) observed that 100% of hepatitis C virus (HCV)\u2010uninfected patients who received a kidney from an HCV\u2010infected deceased donor were cured of HCV with an 8\u2010week regimen of glecaprevir and pibrentasvir (G\/P) initiated 2\u20135 days after transplantation. Following acute and chronic infection with HCV, immune system perturbations have been reported to persist even after viral clearance. The aim of this study was to determine whether HCV viremic kidney recipients in the MYTHIC study experience sustained changes in the soluble inflammatory milieu associated with HCV infection. Among nine patients with HCV viremia at day 3 post\u2010kidney transplant (post\u2010KT D3), IP\u201010, IL\u201010, MIP\u20101\u03b2, and IL\u20108 were significantly elevated from baseline. However, over the subsequent visits, there was a rapid, dramatic reduction back to baseline levels. Among seven patients who were not HCV viremic at post\u2010KT D3, the cytokine levels did not significantly change. HCV\u2010uninfected patients who received a kidney from an HCV\u2010viremic deceased donor and were treated with early G\/P experienced only transient alterations in the soluble inflammatory milieu. These data provide reassuring evidence that there appear to be no persistent cytokine disturbances with transient HCV viremia accompanying HCV donor positive\/recipient negative kidney transplant.<\/jats:p>","DOI":"10.1111\/ctr.14926","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T13:28:02Z","timestamp":1675862882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early initiation of glecaprevir\/pibrentasvir after transplantation of HCV\u2010viremic kidneys into HCV\u2010negative recipients is associated with normalization in the altered inflammatory milieu"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-1633","authenticated-orcid":false,"given":"Myung\u2010Ho","family":"Kim","sequence":"first","affiliation":[{"name":"Liver Center Gastrointestinal Division Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan E.","family":"Sise","sequence":"additional","affiliation":[{"name":"Nephrology Division Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Liver Center Gastrointestinal Division Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Digestive Health &amp; Liver Diseases University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Fontana","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens J.","family":"Kort","sequence":"additional","affiliation":[{"name":"Global Medical Affairs Research &amp; Development AbbVie Inc.  North Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita R.","family":"Alloway","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Durand","sequence":"additional","affiliation":[{"name":"Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Robert S.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Weill Cornell Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh","family":"Levitsky","sequence":"additional","affiliation":[{"name":"Comprehensive Transplant Center Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna L.","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Liver Center Gastrointestinal Division Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter P.","family":"Reese","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Epidemiology and Informatics Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Renal\u2010Electrolyte and Hypertension Division Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond T.","family":"Chung","sequence":"additional","affiliation":[{"name":"Liver Center Gastrointestinal Division Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"unstructured":"US Department of Health and Human Services.Health Resources and Services Administration (HRSA) organ procurement transplant network. 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