{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:39Z","timestamp":1787014059344,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The influence of converting to once daily, extended\u2010release LCP\u2010Tacrolimus (Tac) for those with high tacrolimus variability in kidney transplant recipients (KTRs) is not well\u2010studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010center, retrospective cohort study of adult KTRs converted from Tac immediate release to LCP\u2010Tac 1\u20102 years post\u2010transplant. Primary measures were Tac variability, using the coefficient of variation (CV) and time in therapeutic range (TTR), as well as clinical outcomes (rejection, infections, graft loss, death).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 193 KTRs included with a follow\u2010up of 3.2\u00a0\u00b1\u00a0.7 years and 1.3\u00a0\u00b1\u00a0.3 years since LCP\u2010Tac conversion. Mean age was 52\u00a0\u00b1\u00a013 years; 70% were African American, 39% were female, 16% living donor and 12% donor after cardiac death (DCD). In the overall cohort, tac CV was 29.5% before conversion, which increased to 33.4% after LCP\u2010Tac (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.008). In those with Tac CV &gt;30% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a086), conversion to LCP\u2010Tac reduced variability (40.6% vs. 35.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.019) and for those with Tac CV &gt;30% and nonadherence or med errors (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016), LCP\u2010Tac conversion substantially reduced Tac CV (43.4% vs. 29.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.026). TTR significantly improved for those with Tac CV &gt;30% with (52.4% vs. 82.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.027) or without nonadherence or med errors (64.8% vs. 73.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.005). CMV, BK, and overall infections were significantly higher prior to LCP\u2010Tac conversion. In the overall cohort, 3% had rejection before conversion and 2% after (\n                      <jats:italic>p<\/jats:italic>\n                      = NS). At end of follow\u2010up, graft and patient survival were 94% and 96%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In those with high Tac CV, conversion to LCP\u2010Tac is associated with a significant reduction in variability and improvement in TTR, particularly in those with nonadherence or medication errors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.14941","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T12:57:04Z","timestamp":1676984224000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of converting adult kidney transplant recipients with high tacrolimus variability from twice daily immediate release tacrolimus to once daily LCP\u2010Tacrolimus"],"prefix":"10.1111","volume":"37","author":[{"given":"David J.","family":"Taber","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Transplant Surgery MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-9442","authenticated-orcid":false,"given":"Neha","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Sprague","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-5405","authenticated-orcid":false,"given":"Shikha","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Andrade","sequence":"additional","affiliation":[{"name":"College of Medicine MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Transplant Surgery MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-7154","authenticated-orcid":false,"given":"Maria Aurora Posadas","family":"Salas","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Dubay","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Transplant Surgery MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak","family":"Rohan","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Transplant Surgery MUSC  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15274"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14124"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199529060-00003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2019.1599858"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1618"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"S1","article-title":"Improving Global Outcomes (KDIGO) Transplant Work Group. 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