{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:06:56Z","timestamp":1767773216286,"version":"3.41.2"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pyogenic liver abscess (PLA) is a life\u2010threatening infection in both liver transplant (LT) and non\u2010LT patients. Several risk factors, such as benign and malignant hepatopancreatobiliary diseases and colorectal tumors have been associated with PLA in the non\u2010LT population, and hepatic artery stricture\/thrombosis, biliary stricture, and hepaticojejunostomy in the LT patients. The objective of this study is to compare the outcomes of patients with PLA in LT and non\u2010LT patients and to determine the risk factors associated with patient survival. From January 2000 to November 2020, a total of 296 adult patients were diagnosed of PLA in our institution, of whom 26 patients had previously undergone liver transplantation (LTA group), whereas 263 patients corresponded to the non\u2010LTA population. Seven patients with PLA who had undergone previous kidney transplantation were excluded from this retrospective study. Twenty\u2010six patients out of 1503 LT developed PLA (incidence of 1.7%). Median age was significantly higher in non\u2010LTA patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). No significant differences were observed in therapy. PLA recurrence was significantly higher in LTA than in non\u2010LTA (34.6% vs. 14.8%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008). In\u2010hospital mortality was greater in the LT group than in the non\u2010LT group (19.2%\u00a0vs. 9.1% <jats:italic>p<\/jats:italic>\u00a0=\u00a0.10) and was identified in multivariable analysis as a risk factor for mortality (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.027). Mortality rate during follow\u2010up did not show significant differences between the groups: 34.6% in LTA patients versus 26.2% in non\u2010LTA patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.10). The most common causes of mortality during follow\u2010up were malignancies, Covid\u201019 infection, and neurologic disease. 1\u2010, 3\u2010, and 5\u2010year actuarial patient survival rates were 87.0%, 64.1%, and 50.4%, respectively, in patients of LTA group, and 84.5%, 66.5%, and 51.0%, respectively, in patients with liver abscesses in non\u2010LTA population (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.53). In conclusion, LT was a risk factor for in hospital mortality, but not during long\u2010term follow\u2010up.<\/jats:p>","DOI":"10.1111\/ctr.14966","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T17:39:51Z","timestamp":1679420391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pyogenic liver abscesses in liver transplant recipients versus non\u2010transplant population. Outcome and risk factors of patient survival"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-269X","authenticated-orcid":false,"given":"Carlos","family":"Jim\u00e9nez\u2010Romero","sequence":"first","affiliation":[{"name":"Unit of HPB Surgery and Abdominal Organ Transplantation \u201cDoce de Octubre\u201d University Hospital Department of Surgery, Faculty of Medicine Complutense University  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Marcacuzco","sequence":"additional","affiliation":[{"name":"Unit of HPB Surgery and Abdominal Organ Transplantation \u201cDoce de Octubre\u201d University Hospital Department of Surgery, Faculty of Medicine Complutense University  Madrid 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Surgery, Faculty of Medicine Complutense University  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Garc\u00eda\u2010Sesma","sequence":"additional","affiliation":[{"name":"Unit of HPB Surgery and Abdominal Organ Transplantation \u201cDoce de Octubre\u201d University Hospital Department of Surgery, Faculty of Medicine Complutense University  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Calvo","sequence":"additional","affiliation":[{"name":"Unit of HPB Surgery and Abdominal Organ Transplantation \u201cDoce de Octubre\u201d University Hospital Department of Surgery, Faculty of Medicine Complutense University  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Aguado","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases \u201cDoce de Octubre\u201d Hospital Research Institute (imas12) Faculty of Medicine 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