{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:31:19Z","timestamp":1769927479152,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Heart transplantation (HT) is the gold standard therapy for advanced heart failure, providing excellent long\u2010term outcomes. However, postoperative outcomes are limited by bleeding, infections, and primary graft dysfunction (PGD) that contribute to early mortality after HT. HT candidates with pre\u2010existing hematologic disorders, bleeding, and clotting, may represent a higher risk population. We assessed the short\u2010 and long\u2010term outcomes of patients with pre\u2010existing hematologic disorders undergoing HT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Medical records of all adult patients who received HT from January 2010 to December 2019 at our institution were retrospectively reviewed. Hematologic disorders were identified via chart review and adjudicated by a board\u2010certified hematologist. Inverse probability weighting and multivariable models were used to adjust for potential pretransplant confounders. Four hundred and ninety HT recipients were included, of whom 29 (5.9%) had a hematologic disorder. Hematologic disorders were associated with severe PGD requiring mechanical circulatory support (aOR 3.15 [1.01\u20139.86]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.049), postoperative infections (aOR 2.93 [1.38\u20136.23]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01), and 3\u2010year acute cellular rejection (ACR) (\u22651R\/1B) (aSHR 2.06 [1.09\u20133.87]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03). There was no difference in in\u2010hospital mortality (aOR 1.23 [.20\u20137.58], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.82) or 3\u2010year mortality (aHR 1.58 [.49\u20135.12], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.44).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with hematologic disorders undergoing HT are at increased risk of severe PGD, postoperative infections, and ACR, while in\u2010hospital and 3\u2010year mortality remain unaffected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14974","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T08:48:52Z","timestamp":1679302132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of pre\u2010existing hematologic disorders on morbidity and mortality following heart transplantation: Focus on early graft dysfunction"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5838-8437","authenticated-orcid":false,"given":"Matthew R.","family":"Carey","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine NewYork\u2010Presbyterian Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Ladanyi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine NewYork\u2010Presbyterian Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonatan","family":"Mehlman","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine NewYork\u2010Presbyterian Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-0147","authenticated-orcid":false,"given":"Rebecca L.","family":"Molinsky","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health School of Public Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Eisenberger","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8351-9219","authenticated-orcid":false,"given":"Kevin J.","family":"Clerkin","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine NewYork\u2010Presbyterian Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin G.","family":"Aaron","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine NewYork\u2010Presbyterian\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Takeda","sequence":"additional","affiliation":[{"name":"Division of Cardiac Thoracic &amp; Vascular Surgery Department of Surgery NewYork\u2010Presbyterian Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel T.","family":"Sayer","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine NewYork\u2010Presbyterian Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nir","family":"Uriel","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine NewYork\u2010Presbyterian Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan T.","family":"Demmer","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health School of Public Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo C.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine NewYork\u2010Presbyterian Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melana","family":"Yuzefpolskaya","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine NewYork\u2010Presbyterian Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.07.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.02.027"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.03.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01807"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-199208"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3345"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02519.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22391"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)00458-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.03.049"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.05.080"},{"issue":"6","key":"e_1_2_9_13_1","first-page":"587","article-title":"A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: heart rejection study group. 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