{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:18:00Z","timestamp":1790813880742,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to correlate peripheral blood gene expression profile (GEP) results during the first post\u2010transplant year with outcomes after kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective, multicenter observational study of obtaining peripheral blood at five timepoints during the first post\u2010transplant year to perform a GEP assay. The cohort was stratified based on the pattern of the peripheral blood GEP results: Tx\u2010all GEP results normal, 1 Not\u2010TX had one GEP result abnormal and &gt;1 Not\u2010TX two or more abnormal GEP results. We correlated the GEP results with outcomes after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 240 kidney transplant recipients. The cohort was stratified into the three groups: TX <jats:italic>n<\/jats:italic>\u00a0=\u00a0117 (47%), 1 Not\u2010TX <jats:italic>n<\/jats:italic>\u00a0=\u00a059 (25%) and &gt;1 Not\u2010TX <jats:italic>n<\/jats:italic>\u00a0=\u00a064 (27%). Compared to the TX group, the &gt;1 Not\u2010TX group had lower eGFR (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and more chronic changes on 1\u2010year surveillance biopsy (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.007). Death censored graft survival showed inferior graft survival in the &gt;1 Not\u2010TX group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) but not in the 1 Not\u2010TX group. All graft losses in the &gt;1 Not\u2010TX group occurred after 1\u2010year post\u2010transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude that a pattern of persistently Not\u2010TX GEP assay correlates with inferior graft survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14987","type":"journal-article","created":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T13:40:21Z","timestamp":1680874821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multiple abnormal peripheral blood gene expression assay results are correlated with subsequent graft loss after kidney transplantation"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0367-2008","authenticated-orcid":false,"given":"Raymond L.","family":"Heilman","sequence":"first","affiliation":[{"name":"Department of Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Fleming","sequence":"additional","affiliation":[{"name":"Medical Affairs Transplant Genomics, Inc  Framingham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Medicine Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9318-2437","authenticated-orcid":false,"given":"Byron","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0536-9515","authenticated-orcid":false,"given":"Walter D.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6459-0925","authenticated-orcid":false,"given":"John","family":"Holman","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1392-0792","authenticated-orcid":false,"given":"Mark D.","family":"Stegall","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic  Rochester Minnesota 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