{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:18:09Z","timestamp":1788020289206,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intrathecal morphine (ITM) injection is an effective postoperative analgesic strategy in open or laparoscopic donor hepatectomy; however, the optimal dose has not been determined. In this trial, we compared the post\u2010operative analgesic effects of two doses (300\u00a0vs. 400\u00a0\u03bcg) of ITM injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective randomized non\u2010inferiority trial, 56 donors were divided into either the 300\u00a0\u03bcg or 400\u00a0\u03bcg ITM group (<jats:italic>n<\/jats:italic>\u00a0=\u00a028, each). The primary outcome was the resting pain score at 24\u00a0h postoperatively. Pain scores, cumulative opioid consumption, and side effects (postoperative nausea and vomiting [PONV]) were compared up to 48\u00a0h postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five donors participated in the entire study. The mean resting pain scores at 24\u00a0h after surgery were 1.7\u00a0\u00b1\u00a01.6 and 1.7\u00a0\u00b1\u00a01.1 in the ITM 300 and ITM 400 groups, respectively (mean difference, 0 [95% CI, \u2212.8 to .7], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.978). The upper limit of the 95% CI was lower than the prespecified non\u2010inferiority margin (\u03b4\u00a0=\u00a01), indicating that non\u2010inferiority had been established. The incidence of PONV was lower in the ITM 300 group than in the ITM 400 group at 18 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.035) and 24\u00a0h postoperatively (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.015). There were no significant differences in the resting and coughing pain scores and cumulative opioid consumption at any time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For laparoscopic donor hepatectomy, preoperative ITM 300\u00a0\u03bcg exhibited non\u2010inferior postoperative analgesic effects compared to ITM 400\u00a0\u03bcg, with a lower incidence of PONV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.14996","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T03:55:47Z","timestamp":1681962947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of two doses of intrathecal morphine in laparoscopic donor hepatectomy: A randomized double\u2010blinded non\u2010inferiority trial"],"prefix":"10.1111","volume":"37","author":[{"given":"Seungwon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RyungA","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu\u2010Seong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Man","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Sook","family":"Gwak","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangmin Maria","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaab Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3155-0550","authenticated-orcid":false,"given":"Justin Sangwook","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South 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