{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:22:08Z","timestamp":1770142928691,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytomegalovirus (CMV) is a common infection in abdominal transplant recipients (ATR). Prevention of CMV in the highest risk population (CMV IgG donor+\/recipient\u2010) is critical as CMV is associated with negative outcomes. Guideline recommended prophylactic valganciclovir dosing is 900\u00a0mg daily for 6 months in this population. However, reduced dosing strategies are utilized in practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single center, retrospective study in adult ATR compared full valganciclovir prophylactic dosing (900\u00a0mg daily for 6 months) to reduced dosing (900\u00a0mg daily for 3 months, then 450\u00a0mg daily for 3 months). The primary endpoint was incidence of CMV infection with viral load &gt;1000 IU\/mL. Secondary endpoints included incidence of CMV infection with viral load 200\u20131000 IU\/mL, neutropenia, and leukopenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incidence of CMV infection with viral load &gt;1000 IU\/mL (29%\u00a0vs. 27%, <jats:italic>p<\/jats:italic>\u00a0=\u00a01) or CMV infection with viral load 200\u20101000 IU\/mL (6%\u00a0vs. 12%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.421) did not differ significantly between 68 ATR in reduced and full dosing groups, as well as incidence of leukopenia (94%\u00a0vs. 97%, <jats:italic>p<\/jats:italic>\u00a0=\u00a01) and neutropenia (77%\u00a0vs. 70%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.586).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no difference in the incidence of CMV infection, neutropenia, or leukopenia of the two dosing regimens, although time to CMV diagnosis was different.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15041","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T17:48:44Z","timestamp":1685555324000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reduced dosing versus full dosing valganciclovir for prophylaxis of cytomegalovirus in high\u2010risk abdominal transplant recipients"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6877-0907","authenticated-orcid":false,"given":"Maura L.","family":"Kreiser","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Experimental Therapeutics University of North Carolina Eshelman School of Pharmacy  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Experimental Therapeutics University of North Carolina Eshelman School of Pharmacy  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7649-4404","authenticated-orcid":false,"given":"Kristen R.","family":"Szempruch","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of North Carolina Medical Center  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Chargualaf","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of North Carolina Medical Center  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.DMIH2-0022-2015"},{"key":"e_1_2_8_3_1","unstructured":"Cytomegalovirus (CMV) and Congenital CMV Infection Centers for Disease Control and Prevention"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23539"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24450"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002191"},{"key":"e_1_2_8_7_1","unstructured":"GenentechUSA Inc. Valcyte Prescribing Information. Accessed April 7 2022.https:\/\/www.gene.com\/download\/pdf\/valcyte_prescribing.pdf"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13512"},{"key":"e_1_2_8_9_1","unstructured":"University of North Carolina Medical Center.University of North Carolina Medical Center Abdominal Transplant Guideline (Scut Monkey).2017."},{"key":"e_1_2_8_10_1","unstructured":"University of North Carolina Medical Center.University of North Carolina Medical Center Abdominal Transplant Guideline.2020."},{"key":"e_1_2_8_11_1","unstructured":"GraphPad. Prism. Accessed April 7 2022.https:\/\/www.graphpad.com\/"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000570"},{"issue":"5","key":"e_1_2_8_13_1","first-page":"526","article-title":"Efficacy and safety of low\u2010dose versus standard\u2010dose valganciclovir for prevention of cytomegalovirus disease in intermediate\u2010risk kidney transplant recipients","volume":"14","author":"Halim MA","year":"2016","journal-title":"Exp Clin Transplant"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2018.0020"},{"issue":"1","key":"e_1_2_8_15_1","first-page":"156","article-title":"Successful cost\u2010effective prevention of cytomegalovirus disease in kidney transplant recipients using low\u2010dose valganciclovir","volume":"15","author":"Gheith O","year":"2017","journal-title":"Exp Clin Transplant"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25047"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12609"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13713"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000570"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12349"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/427506"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq143"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.18433\/J3805B"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T11:30:19Z","timestamp":1697801419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,31]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/ctr.15041"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15041","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,31]]},"assertion":[{"value":"2022-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15041"}}