{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:08:17Z","timestamp":1790204897648,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence of malignancies after successful kidney transplantation has historically been higher than in the general population, with adverse impact on clinical outcomes. However, uncertainty remains as to which cancers occur at what time points after kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a longitudinal cohort study to investigate the temporal trends and topographic patterns of de novo malignancies to optimize surveillance protocols and improve transplant outcome in renal transplant recipients. Measurement of death and cancer events was performed to calculate the cumulative risk of events of interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2000 and 2013, 3169 renal transplant recipients were retrospectively screened; 3035 (96%) of them met eligibility criteria and were evaluated with a follow\u2010up of 27612 person\u2010years. There was suboptimal overall survival and malignancy\u2010free survival in renal transplant recipients compared to reference groups (HR: 1.65; 95% CI: 1.50\u20131.82; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001; HR: 2.33; 95% CI: 2.04\u20132.66; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001, respectively). Among renal transplant recipients, urological malignancies were predominant (57.5%), followed by digestive tract malignancies (21.4%). The cancer risks of the urinary bladder and upper urinary tract were lower in male subjects (HR: .48; 95% CI: .33\u2013.72; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001; HR: .34; 95% CI: .20\u2013.59; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001, respectively). The temporal trends of urological malignancies among renal transplant recipients were expressed in a bimodal pattern, with M\u2010shaped peaks at 3 and 9 years, with gender disparity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In renal transplant recipients, cancer occurrences are shown as M\u2010shaped twin peaks. Our study highlights that specific customized 'targeted' strategies for cancer surveillance programs are required to optimize posttransplant care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15047","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T15:06:52Z","timestamp":1686582412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Temporal trends of de novo urological malignancy in renal transplant recipients without a cancer history: A longitudinal cohort study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4302-1904","authenticated-orcid":false,"given":"Kevin","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Urology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"School of Medicine National Yang\u2010Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun\u2010Yuan","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Urology Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"School of Medicine National Yang\u2010Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Applied Chemistry National Chi Nan University  Puli Nantou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16502"},{"key":"e_1_2_9_4_1","unstructured":"ANZDATA Registry. 43rd Report Chapter 7:Kidney Transplantation. 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