{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:20:40Z","timestamp":1782944440650,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Enhanced recovery after surgery (ERAS) protocols have been associated with a reduction in opioid consumption and a hastening in recovery in abdominal surgery. However, their impact on laparoscopic donor nephrectomy (LDN) has not been fully elucidated. The aim of this study is to evaluate opioid consumption and other relevant outcome measures before and after implementation of a unique LDN ERAS protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>244 LDN patients were included in this retrospective cohort study. Forty\u2010six underwent LDN prior to implementation of ERAS, whereas 198 patients received ERAS perioperative care. The primary outcome was daily oral morphine equivalent (OME) consumption averaged over the entire postoperative stay. Due to removal of preoperative oral morphine from the protocol partway through the study period, the ERAS group was further subdivided into morphine recipients and non\u2010recipients for subgroup analysis. Secondary outcomes included the incidence of postoperative nausea and vomiting (PONV), length of stay, pain scores, and other relevant measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ERAS donors consumed significantly fewer average daily OMEs than Pre\u2010ERAS donors (21.5\u00a0vs. 37.6, respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001).\u00a0There were no statistically significant differences in OME consumption between morphine recipients and non\u2010recipients. The ERAS group experienced less PONV (44.4% requiring one or more rescue antiemetic postoperatively, vs. 60.9% of Pre\u2010ERAS donors; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A protocol pairing lidocaine and ketamine with a comprehensive approach to preoperative PO intake, premedication, intraoperative fluid management and postoperative pain control is associated with reduced opioid consumption in LDN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15051","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T14:45:02Z","timestamp":1687185902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluating a unique enhanced recovery protocol in laparoscopic donor nephrectomy: A single center experience"],"prefix":"10.1111","volume":"37","author":[{"given":"Samuel 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W.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4647-1372","authenticated-orcid":false,"given":"Kathirvel","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Abdelwahid","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center Pittsburgh Pennsylvania 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