{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:19:10Z","timestamp":1780568350635,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006501","name":"Cystic Fibrosis Foundation Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Re\u2010transplant is an option for those who develop end\u2010stage lung disease due to rejection; however, little data exist following re\u2010transplantation in cystic fibrosis (CF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the Canadian CF Registry and US CF Foundation Patient Registry supplemented with data from United Network for Organ Sharing were used. Individuals who underwent a 2nd lung transplant between 2005 and 2019 were included. The Kaplan\u2010Meier method was used to estimate the probability of survival post\u2010second transplant at 1, 3, and 5\u2010years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of those people who were waitlisted for a second transplant (<jats:italic>N<\/jats:italic>\u00a0=\u00a0818), a total of 254 (31%) died waiting, 395 (48%) were transplanted and 169 (21%) people were alive on the waitlist. Median survival time after 2nd lung transplant was 3.3 years (95% CI: 2.8\u20104.1). The 1\u2010, 3\u2010 and 5\u2010year survival rates were 77.4% (95% CI: 73.1\u201082%), 52% (95% CI: 46.7\u201058%) and 39.4% (95% CI: 34.1\u201045.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survival following second lung transplant in CF patients is lower than estimates following the first transplant. Over half of subjects who are potentially eligible for a second transplant die without receiving a second organ. This warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15097","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T03:09:45Z","timestamp":1691723385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cystic fibrosis survival outcomes following second lung transplant: The north American experience"],"prefix":"10.1111","volume":"37","author":[{"given":"Moayad","family":"Alshehri","sequence":"first","affiliation":[{"name":"Department of Respirology St. Michael's Hospital Toronto Ontario Canada"},{"name":"Unit of Pulmonology Internal Medicine Department King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen J.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care and Sleep Medicine Department of Medicine University of Washington Medical Center Seattle 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C.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Foundation Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5106-0607","authenticated-orcid":false,"given":"Elizabeth","family":"Cromwell","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Foundation Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Ostrenga","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Foundation Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Faro","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Foundation Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Elbert","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Foundation Bethesda Maryland 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Michael's Hospital Toronto Ontario Canada"},{"name":"Keenan Research Centre Li Ka Shing Knowledge Institute of St Michael's Hospital Toronto Ontario Canada"},{"name":"Institute of Health Policy Management and Evaluation University of Toronto Toronto Ontario 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