{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:26:05Z","timestamp":1781868365714,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The gastrointestinal (GI) tract is a major human adenovirus (HAdV) replication site in patients undergoing hematopoietic stem cell transplantation (HSCT), yet the prevalence and correlates of HAdV GI infection in this setting have remained poorly recognized, especially among adult HSCT recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design or methods<\/jats:title><jats:p>We retrospectively studied the prevalence and risk factors of HAdV GI\u2010tissue infection in HSCT recipients (73 adults and 15 children) with GI symptoms who underwent GI\u2010tissue biopsy between January\u20102012 and December\u20102017. The presence of HAdV in the GI tissues was determined by real\u2010time PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HAdV GI\u2010tissue infection was detected in 21 (23.9%) patients, with similar infection rates identified in adults and children. GI\u2010tissue detection was more common at late (&gt;100 days) compared to early times post\u2010transplantation (50%\u00a0vs. 12.9%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). The presence of bloody diarrhea, Arab ethnicity (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.014) and concurrent cytomegalovirus GI\u2010tissue detection (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.025) were significantly correlated with HAdV GI\u2010tissue infection, while chronic graft versus host disease was of borderline association (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.055).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings reveal a high rate and new clinical\u2010demographic correlates of HAdV GI\u2010tissue infection in adult and pediatric HSCT recipients with GI symptoms. The findings highlight the need for future prospective studies to assess the relatedness of HAdV infection to the GI symptoms, and the prevalence, impact, and treatment of HAdV GI infection in HSCT recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15098","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T03:11:04Z","timestamp":1691723464000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["High rate of adenovirus detection in gastrointestinal biopsies of symptomatic stem cell transplant recipients"],"prefix":"10.1111","volume":"37","author":[{"given":"Hagar Z.","family":"Pikkel\u2010Geva","sequence":"first","affiliation":[{"name":"Faculty of Medicine the Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigal","family":"Grisariu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine the Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Bone Marrow Transplantation and Cancer Immunotherapy Department Hadassah University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mila","family":"Rivkin","sequence":"additional","affiliation":[{"name":"Clinical Virology Unit Hadassah Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Stepensky","sequence":"additional","affiliation":[{"name":"Faculty of Medicine the Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Bone Marrow Transplantation and Cancer Immunotherapy Department Hadassah University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Strahilevitz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine the Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Department of Clinical Microbiology and Infectious Diseases Hadassah Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Averbuch","sequence":"additional","affiliation":[{"name":"Faculty of Medicine the Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Pediatric Infectious Diseases Unit Faculty of Medicine, Hadassah Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caplan","family":"Orit","sequence":"additional","affiliation":[{"name":"Clinical Virology Unit Hadassah Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4292-6376","authenticated-orcid":false,"given":"Ehud","family":"Even\u2010Or","sequence":"additional","affiliation":[{"name":"Faculty of Medicine the Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Bone Marrow Transplantation and Cancer Immunotherapy Department Hadassah University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Zaidman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine the Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Bone Marrow Transplantation and Cancer Immunotherapy Department Hadassah University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Zimran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine the Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Bone Marrow Transplantation and Cancer Immunotherapy Department Hadassah University Medical Center  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana G.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Faculty of Medicine the Hebrew University of Jerusalem  Jerusalem Israel"},{"name":"Clinical Virology Unit Hadassah Hebrew University Medical Center  Jerusalem 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