{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:59:27Z","timestamp":1759229967469,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study analyzes heart transplantation funding provided by the National Natural Science Foundation of China (NSFC) between 1986 and 2022. The findings offer an objective and scientific reference for heart transplantation research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CiteSpace visualization was used to present keywords in heart transplantation research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1986 to 2022, the NFSC disbursed \u00a5117.68 million to fund 259 projects related to heart transplantation. Hubei, Shanghai, Beijing, Guangdong, and Heilongjiang received the most funding. General and youth science fund projects accounted for 58.69% and 30.50%, respectively. The main discipline category was organ transplantation and transplantation immunity, accounting for 40.93%. Research hotspots included \u201cimmune tolerance,\u201d \u201crejection reaction,\u201d \u201ct cell\u201d \u201cdendritic cell,\u201d \u201cstem cell,\u201d and \u201ctransplantation tolerance.\u201d Research foci were \u201crejection reaction,\u201d \u201cheart failure,\u201d \u201cimmune tolerance,\u201d \u201cheart transplantation,\u201d \u201cstem cell,\u201d \u201csuppressor cell,\u201d \u201cdendritic cell,\u201d \u201cdilated cardiomyopathy,\u201d and \u201ct cell.\u201d In the past 5\u00a0years, the research frontier has targeted \u201ctransplantation tolerance,\u201d \u201cischemia\u2010reperfusion injury,\u201d and \u201cheart transplantation.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Continuous NSFC funding for heart transplantation research has promoted the development of disciplines and cultivation of talent. Novel technologies (e.g., artificial hearts and donor maintenance) have generated new requirements for heart transplantation research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15108","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:48:46Z","timestamp":1693212526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Basic situation and trend analysis in heart transplantation research funded by the National Natural Science Foundation of China"],"prefix":"10.1111","volume":"37","author":[{"given":"Xianyu","family":"Xie","sequence":"first","affiliation":[{"name":"Fujian Medical University Union Hospital  Fuzhou City Fujian Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7356-2149","authenticated-orcid":false,"given":"Qinde","family":"Wu","sequence":"additional","affiliation":[{"name":"Fujian Medical University Union Hospital  Fuzhou City Fujian Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1002\/ejhf.1236"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.13507\/j.issn"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"12","article-title":"Proposal application, peer review and funding of NSFC in 2020: an overview","volume":"35","author":"Zhao YH","year":"2021","journal-title":"Bulletin of National Natural Science Foundation of China"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.12102\/j.issn.1672\u20101349.2023.02.009"},{"issue":"2","key":"e_1_2_10_6_1","first-page":"1","article-title":"Science mapping: a systematic review of the literature","volume":"2","author":"Chen C","year":"2017","journal-title":"J Data Inf Sci"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.3969\/j.issn.1671\u20103982.2020.06.011"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.3969\/j.issn.1003\u20102053.2015.02.009"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1517\/14712598.2012.674507"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1002\/asi.20317"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.12189\/j.issn.1672\u20108505.2020.02.013"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1111\/ajt.15339"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1111\/ctr.13651"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.3389\/fimmu.2021.664577"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.3967\/bes2022.079"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1016\/j.jacc.2019.03.478"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.3390\/jcm11123425"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.3390\/jcm11092665"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1016\/j.healun.2018.11.013"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T14:53:24Z","timestamp":1704898404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/ctr.15108"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15108","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2023,8,28]]},"assertion":[{"value":"2023-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15108"}}