{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:58:13Z","timestamp":1785373093165,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrence after Cytomegalovirus (CMV) infection in heart transplant recipients is difficult to predict, in spite of its high incidence. Secondary prophylaxis could reduce this burden; however, its duration remains unestablished. We evaluated the QuantiFERON\u00ae\u2010CMV test to see if it could predict CMV recurrence and help optimize the duration of secondary prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational retrospective single center study included all heart transplant recipients who developed CMV infection between 2019 and 2021, with the CD8+ T\u2010cell\u2010mediated CMV immunity QuantiFERON\u00ae\u2010CMV test assessed at the time of (val)ganciclovir curative treatment completion. The main outcomes were CMV recurrence and duration of secondary prophylaxis. Secondary outcomes included immunosuppressive regimen, rejection, lymphocyte count, CMV viral load, infection type, and duration as possible confounding factors for recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 15 patients included, five (33%) experienced recurrence, of whom three (60%) had a positive QuantiFERON\u00ae\u2010CMV test. The duration of secondary prophylaxis was similar regardless of QF\u2010CMV positivity. No confounding factor was significantly associated with CMV recurrence; however, it occurred in only 1\/7 (14%) of the patients receiving an everolimus\u2010containing immunosuppressive regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the population of heart transplant recipients, most of whom received ATG\u2010based induction, the QuantiFERON\u00ae\u2010CMV assay may not accurately predict CMV recurrence and would have not helped refining the duration of secondary prophylaxis in our patients. Other cell\u2010mediated immunity tests and strategies in this specific population, including everolimus\u2010containing regimens, may help predict and manage CMV recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15109","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T07:33:17Z","timestamp":1693294397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reliability of QuantiFERON\u00ae\u2010CMV in predicting CMV recurrence in heart transplant recipients: A single\u2010center retrospective study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6753-7326","authenticated-orcid":false,"given":"Kevin","family":"Sermet","sequence":"first","affiliation":[{"name":"Service des maladies infectieuses et tropicales CHU Lille  Lille France"},{"name":"CNRS Inserm Institut Pasteur Lille U1019 \u2013 UMR 9017 \u2013 CIIL \u2013 Center for Infection and Immunity of Lille University of Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8213-7865","authenticated-orcid":false,"given":"C\u00e9line","family":"Goeminne","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-0773","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Hantz","sequence":"additional","affiliation":[{"name":"INSERM CHU Limoges RESINFIT U1092 University of Limoges  Limoges France"},{"name":"Laboratoire de Bact\u00e9riologie\u2010Virologie\u2010Hygi\u00e8ne National Reference Center for Herpesviruses (NRCHV) CHU Limoges  Limoges 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ULR3610 Universit\u00e9 de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2608-9790","authenticated-orcid":false,"given":"Karine","family":"Faure","sequence":"additional","affiliation":[{"name":"Service des maladies infectieuses et tropicales CHU Lille  Lille France"},{"name":"CNRS Inserm Institut Pasteur Lille U1019 \u2013 UMR 9017 \u2013 CIIL \u2013 Center for Infection and Immunity of Lille University of Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-1421","authenticated-orcid":false,"given":"Sophie","family":"Alain","sequence":"additional","affiliation":[{"name":"INSERM CHU Limoges RESINFIT U1092 University of Limoges  Limoges France"},{"name":"Laboratoire de Bact\u00e9riologie\u2010Virologie\u2010Hygi\u00e8ne National Reference Center for Herpesviruses (NRCHV) CHU Limoges  Limoges 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