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Therefore, identifying the potential risk factors of BKV\u2010HC after allo\u2010HCT is crucial to improve prognosis and for early prevention. However, the risk factors for BKV\u2010HC remain debatable. Therefore, we conducted a systematic review and meta\u2010analysis to identify the risk factors for BKV\u2010HC, for early prevention of the occurrence of BKV\u2010HC and to improve the quality of life and prognosis of allo\u2010HCT recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched relevant studies from PubMed, EMBASE, and the Cochrane Library up to February 2023. The odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of all risk factors were calculated to evaluate their effects on the occurrence of BKV\u2010HC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 11 studies involving 2556 allo\u2010HCT recipients were included in this meta\u2010analysis. All included studies were retrospective and published between 2013 and 2022. We found that male sex (OR\u00a0=\u00a01.32; 95% CI, 1.07\u20131.62; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.009, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a034%), haploidentical donor (OR\u00a0=\u00a01.84; 95% CI, 1.18\u20132.87; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a023%), myeloablative conditioning (OR\u00a0=\u00a01.76; 95% CI, 1.36\u20132.28; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a045%), acute graft versus host disease (aGVHD) (OR\u00a0=\u00a02.73; 95% CI, 2.02\u20133.69; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a046%), chronic graft versus host disease (cGVHD) (OR\u00a0=\u00a01.71; 95% CI, 1.12\u20132.60; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%), and cytomegalovirus (CMV) reactivation (OR\u00a0=\u00a03.13; 95% CI, 1.12\u20138.78; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a079%) were significantly associated with BKV\u2010HC in the univariable analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our meta\u2010analysis indicated that male sex, haploidentical donor, myeloablative conditioning, aGVHD, cGVHD, and CMV reactivation were potential risk factors for BKV\u2010HC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15121","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T14:57:09Z","timestamp":1694098629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Risk factors for BK virus\u2010associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"37","author":[{"given":"Xuemei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Quality and Safety Control Zhongnan Hospital of Wuhan University  Wuhan 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