{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:47:33Z","timestamp":1790934453263,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The relationship between donor age and adolescent heart transplant outcomes remains incompletely understood. We aimed to explore the effect of donor\u2010recipient age difference on survival after adolescent heart transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The United Network for Organ Sharing database was used to identify 2,855 adolescents aged 10\u201317 years undergoing isolated primary heart transplantation from 1\/1\/2000 to 12\/31\/2022. The primary outcome was 10\u2010year post\u2010transplant survival. Multivariable Cox regression identified predictors of mortality after adjusting for donor and recipient characteristics. A restricted cubic spline assessed the non\u2010linear association between donor\u2010recipient age\u2010difference and the adjusted relative mortality hazard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median donor\u2010recipient age\u2010difference was +3 (range \u201013 to +47) years, and 17.7% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0504) of recipients had an age\u2010 difference\u00a0&gt;\u00a010 years. Recipients with an age\u2010difference\u00a0&gt;\u00a010 years had a less favorable pre\u2010transplant profile, including a higher incidence of priority status 1A (81.6%, <jats:italic>n =<\/jats:italic> 411 vs. 73.6%, <jats:italic>n =<\/jats:italic> 1730; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). The 10\u2010year survival rate was 54.6% (95% confidence interval (CI) 48.8\u2013 60.4) among recipients with a donor\u2010recipient age\u2010difference\u00a0&gt;\u00a010 years and 66.9% (95% CI: 64.4\u201369.4) among those with an age\u2010difference \u226410 years. An age\u2010difference\u00a0&gt;\u00a010 years was an independent predictor of mortality (hazard ratio 1.43, 95% CI: 1.18\u20131.72, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Spline analysis demonstrated that the adjusted mortality hazard increased with increasingly positive donor\u2010recipient age\u2010difference and became significantly higher at an age\u2010difference of 11 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A donor\u2010recipient age\u2010difference\u00a0&gt;\u00a011 years is independently associated with higher long\u2010term mortality after adolescent heart transplantation. This finding may help inform acceptable donor selection practice for adolescent heart transplant candidates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15146","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T12:30:27Z","timestamp":1696077027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of donor\u2010recipient age\u2010difference in adolescent heart transplantation"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6673-5841","authenticated-orcid":false,"given":"George","family":"Gill","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Mujeeb","family":"Zubair","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University of Michigan Congenital Heart Center C. S. Mott Children's Hospital  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2475-4312","authenticated-orcid":false,"given":"Qiudong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-1831","authenticated-orcid":false,"given":"Jason","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of General Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-097X","authenticated-orcid":false,"given":"Asishana","family":"Osho","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University of Michigan Congenital Heart Center C. S. Mott Children's Hospital  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt R.","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Michigan Congenital Heart Center C. S. Mott Children's Hospital  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5728-0152","authenticated-orcid":false,"given":"Dominic","family":"Emerson","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Bowdish","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Chikwe","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Fynn\u2010Thompson","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.09.018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16492"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.09.026"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.15902"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.07.019"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.11.009"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.01.1345"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.08.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01300.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12734"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2021.10039"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T14:52:59Z","timestamp":1704898379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,30]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/ctr.15146"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15146","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,30]]},"assertion":[{"value":"2023-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15146"}}