{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:03Z","timestamp":1753878603889,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Outcomes analyzing conversion from IR\u2010tacrolimus (IR) to LCP\u2010tacrolimus (LCP) in obesity are limited. This was a retrospective longitudinal cohort study of patients converted from IR to LCP from June 2019 to October 2020. Primary outcomes were conversion ratios for weight\u2010based dose at a steady\u2010state therapeutic level and identification of appropriate dosing weight. Other outcomes included tacrolimus coefficient of variation (CV), time in therapeutic range (TITR), adverse events, infections, donor specific antibodies (DSAs), and acute rejection. A total of 292 patients were included; 156 and 136 patients with a BMI\u00a0&lt;\u00a030 and BMI\u00a0\u2265\u00a030\u00a0kg\/m<jats:sup>2<\/jats:sup>, respectively. Baseline characteristics were similar, except for pancreas transplant, diabetes, and HLA mismatch. IR to LCP conversion ratio ranged from .73 to .79. Mean LCP dose was similar (.08 vs. .07\u00a0mg\/kg\/day for BMI\u00a0&lt;\u00a030 and BMI\u00a0\u2265\u00a030\u00a0kg\/m<jats:sup>2<\/jats:sup>, respectively); there was a significant difference in IR and LCP mg\/kg dosing at steady state with TBW (.11\u00a0mg\/kg vs.09\u00a0mg\/kg and .08\u00a0mg\/kg vs. .06\u00a0mg\/kg, respectively). The most appropriate dosing weight was adjusted body weight (AdjBW), consistent across IR and LCP steady\u2010state doses, and might yield more accurate steady\u2010state dosing requirements. In multivariable modeling, BMI was a significant predictor of steady state mg\/kg dosing at therapeutic goal for total body weight (TBW), but not ideal body weight (IBW) or AdjBW.<\/jats:p>","DOI":"10.1111\/ctr.15149","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:43:23Z","timestamp":1696351403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of obesity on the conversion of immediate\u2010release tacrolimus to extended\u2010release tacrolimus in kidney transplant recipients"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-9794","authenticated-orcid":false,"given":"Jessica","family":"Newman","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-9442","authenticated-orcid":false,"given":"Neha","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-5405","authenticated-orcid":false,"given":"Shikha","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor","family":"Sprague","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinayak","family":"Rohan","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"DuBay","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7273-4589","authenticated-orcid":false,"given":"David","family":"Taber","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Department of Pharmacy Ralph H Johnson VAMC  Charleston South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.11.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16502"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7191.1104"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088\u2010200443100\u201000001"},{"key":"e_1_2_8_6_1","unstructured":"FDA Drug Shortages. Accessed June 1 2022.https:\/\/www.accessdata.fda.gov\/scripts\/drugshortages\/dsp_ActiveIngredientDetails.cfm?AI=Tacrolimus+Capsules&st=c&tab=tabs\u20103&i=24&panel=24"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2021.1974399"},{"key":"e_1_2_8_8_1","unstructured":"EnvarsusXR(tacrolimus extended\u2010release) [prescribing information] Cary Veloxis Pharmaceuticals Inc.2018."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/08971900211021054"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14529"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010015\u20100340\u20105"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14099"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026854"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000644"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010022\u201003323\u20100"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000028"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2015.87"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T14:52:25Z","timestamp":1704898345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,3]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/ctr.15149"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15149","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2023,10,3]]},"assertion":[{"value":"2023-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15149"}}