{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:45:39Z","timestamp":1763037939288,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent innovations in temperature\u2010controlled cardiac transportation allow for static hypothermic preservation of transplant organs during transportation. We assessed differences in donor\u2010derived cell\u2010free DNA (dd\u2010cfDNA) using the SherpaPak cardiac transport system (SCTS) and traditional ice transportation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010organ heart transplant recipients between January 2020 and January 2022 were included if they had dd\u2010cfDNA measures \u22646\u00a0weeks post\u2010transplant along with the baseline biopsy at 6\u00a0weeks as part of the surveillance protocol and no biopsy\u2010confirmed rejection \u226490 days. Elevated dd\u2010cfDNA \u2265.20% were compared between groups using logistic regression including a subject effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 65 hearts transplanted, 30 were transported with SCTS and 35 on ice. Recipient characteristics were similar between groups. Donors in the SCTS group were older (34\u00a0vs. 40 years, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04) with a longer total ischemic time (171\u00a0vs. 212 min, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002). Recipients in the SCTS group had a greater risk of elevated dd\u2010cfDNA unadjusted and adjusted for donor age, and prolonged ischemic times\u00a0&gt;\u00a03.5\u00a0h (Unadjusted odds ratio: 4.9, 95%\u2010CI: 1.08\u201322.5, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.039 and Adjusted odds ratio: 5.5, 95%\u2010CI: 1.03\u201329.6, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.046). Primary graft dysfunction rates and 1\u2010year mortality were comparable between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated dd\u2010cfDNA in patients procured with SCTS may indicate that graft injury was not negated relative to ice transport. However, there were no clinical differences noted in short or long\u2010term outcomes including mortality despite a longer ischemic time in the SCTS group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15151","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T17:40:22Z","timestamp":1699033222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early elevated donor\u2010derived cell\u2010free DNA levels in heart transplant recipients following precision\u2010controlled cardiac transport system or ice\u2010cooled organ transport"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-3957","authenticated-orcid":false,"given":"Amit","family":"Alam","sequence":"first","affiliation":[{"name":"Division of Cardiology New York University Grossman School of Medicine New York University Langone Health  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-9214","authenticated-orcid":false,"given":"Johanna S.","family":"van Zyl","sequence":"additional","affiliation":[{"name":"Texas A&amp;M University Health Science Center College of Medicine  Dallas Texas USA"},{"name":"Baylor Scott &amp; White Research Institute Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aasim","family":"Afzal","sequence":"additional","affiliation":[{"name":"Center for Advanced Heart and Lung Disease Baylor University Medical Center Baylor Scott &amp; White Health  Dallas Texas USA"},{"name":"The Heart Hospital Baylor Plano Baylor Scott &amp; White Health  Plano Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7200-8755","authenticated-orcid":false,"given":"Joost","family":"Felius","sequence":"additional","affiliation":[{"name":"Texas A&amp;M University Health Science Center College of Medicine  Dallas Texas USA"},{"name":"Baylor Scott &amp; White Research Institute Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4894-396X","authenticated-orcid":false,"given":"Shelley A.","family":"Hall","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Research Institute Baylor Scott &amp; White Health  Dallas Texas USA"},{"name":"Center for Advanced Heart and Lung Disease Baylor University Medical Center Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan M.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Research Institute Baylor Scott &amp; White Health  Dallas Texas USA"},{"name":"Center for Advanced Heart and Lung Disease Baylor University Medical Center Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-1324","authenticated-orcid":false,"given":"Sandra A.","family":"Carey","sequence":"additional","affiliation":[{"name":"Center for Advanced Heart and Lung Disease Baylor University Medical Center Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd\u201020\u20101827"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.04.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14707"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000004416"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.02.027"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15339"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.09.019"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.01.067"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/mat.0000000000001844"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.36628\/ijhf.2021.0042"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010013\u20100131\u20109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1959"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.01.1398"},{"issue":"3","key":"e_1_2_10_15_1","article-title":"Impact of donor and recipient characteristics on early post\u2010transplant donor\u2010derived cell\u2010free DNA (dd\u2010cfDNA) scores [abstract]","volume":"22","author":"Alam A","year":"2022","journal-title":"Am J Transplant"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.03.013"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14549"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T14:53:28Z","timestamp":1704898408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,3]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/ctr.15151"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15151","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2023,11,3]]},"assertion":[{"value":"2023-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15151"}}