{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:24Z","timestamp":1753878444559,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>With the introduction of direct\u2010acting antiviral therapies (DAAs), the non\u2010use rate of hepatitis C virus (HCV)\u2010positive donor organs (D+) has decreased significantly. We present the donor, recipient, and transplant allograft characteristics, along with recipient outcomes, in one of the largest cohorts of HCV\u2010D+ transplants into HCV\u2010na\u00efve recipients (R\u2212).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Charts of HCV D+\/R\u2212 kidney (KT), liver (LT), and simultaneous liver\u2010kidney (SLKT) transplant recipients between January 2019 and July 2022 were reviewed. Primary outcomes of interest included waitlist times and 1\u2010year graft failure. Secondary outcomes included hospital and intensive care unit length of stay, post\u2010transplant complications, effectiveness of DAA therapy, and characteristics of patients who relapsed from initial DAA therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five HCV D+\/R\u2212 transplants at our center [42 KT (26 nucleic acid testing positive [NAT+], 16 NAT\u2212), 12 LT (eight NAT+, four NAT\u2212), and one SLKT (NAT+)] had a median waitlist time of 69\u00a0days for KT, 87\u00a0days for LT, and 15\u00a0days for SLKT. There were no graft failures at 1\u00a0year. All viremic recipients were treated with a 12\u2010week course of DAAs, of which 100% achieved end of treatment response (EOTR)\u201485.7% (<jats:italic>n<\/jats:italic>\u00a0=\u00a030) achieved sustained virologic response (SVR) and 14.3% relapsed (<jats:italic>n<\/jats:italic>\u00a0=\u00a05; four KT, one LT). All relapsed recipients were retreated and achieved SVR. The most common post\u2010transplantation complications include BK virus infection (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) for KT and non\u2010allograft infections (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) for LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study has demonstrated no graft failures or recipient deaths at 1\u00a0year, and despite a 14.3% relapse rate, we achieved 100% SVR. Complications rates of D+\/R\u2212 appeared comparable to national D\u2212\/R\u2212 complication rates. Further studies comparing D+\/R\u2212 to D\u2212\/R\u2212 outcomes are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15161","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T10:20:06Z","timestamp":1697451606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of kidney, liver, and simultaneous liver and kidney transplants from hepatitis c infected donors to hepatitis c na\u00efve recipients: A large single center experience"],"prefix":"10.1111","volume":"38","author":[{"given":"Hany","family":"Elbeshbeshy","sequence":"first","affiliation":[{"name":"Center for Abdominal Transplantation SSM Health Saint Louis University Hospital  St. Louis Missouri 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