{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:52:23Z","timestamp":1763621543032,"version":"3.41.2"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aim<\/jats:title><jats:p>Limited data are available regarding pre\u2010liver transplantation (LT) bacteremia in adults with end\u2010stage liver disease. In this study, we investigated the risk factors independently associated with pre\u2010LT bacteremia and their effects on clinical outcomes of LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study performed between 2010 and 2021 included 1287 LT recipients. The study population was categorized into patients with pre\u2010LT bacteremia and those without pre\u2010LT infection. Pre\u2010LT bacteremia was defined as bacteremia detected within 90\u00a0days before LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1287 LT recipients, 92 (7.1%) developed pre\u2010LT bacteremia. The mean interval between bacteremia and LT was 28.3\u00a0\u00b1\u00a019.5\u00a0days. Of these 92 patients, seven (7.6%) patients died after LT. Of the 99 microorganisms isolated in this study, gram\u2010negative bacteria were the most common microbes (72.7%). Bacteremia was mainly attributed to spontaneous bacterial peritonitis. The most common pathogen isolated was <jats:italic>Escherichia coli<\/jats:italic> (25.2%), followed by <jats:italic>Klebsiella pneumoniae<\/jats:italic> (18.2%), and <jats:italic>Staphylococcus aureus<\/jats:italic> (15.1%). Multivariate analysis showed that massive ascites (adjusted odds ratio [OR] 1.67, 95% confidence Interval [CI] 1.048\u20132.687) and a prolonged international normalized ratio for prothrombin time (adjusted OR 1.13, 95% CI 1.074\u20131.257) were independent risk factors for pre\u2010LT bacteremia in patients with end\u2010stage liver disease. Intensive care unit and in\u2010hospital stay were significantly longer, and in\u2010hospital mortality was significantly higher among LT recipients with pre\u2010LT bacteremia than among those without pre\u2010LT infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights predictors of pre\u2010LT bacteremia in patients with end\u2010stage liver disease. Pre\u2010LT bacteremia increases the post\u2010transplantation mortality risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15163","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T08:19:45Z","timestamp":1697098785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk factors for pre\u2010transplantation bacteremia in adults with end\u2010stage liver disease: Effects on outcomes of liver transplantation"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0963-5347","authenticated-orcid":false,"given":"Ing\u2010Kit","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital, Chang Gang University, College of Medicine  Taoyuan 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