{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:03:10Z","timestamp":1780066990440,"version":"3.54.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Our study hypothesis was that once daily dosing of extended\u2010release tacrolimus (XRT) would be a safe and effective immunosuppression (IS) with the potential to decrease adverse events (AEs) associated with immediate release tacrolimus (IRT) after liver transplantation (LT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients receiving LT at our center received rabbit anti\u2010thymocyte globulin (RATG) induction therapy. Eligible patients were randomized in a 1:1 fashion to receive either XRT or IRT. Antimicrobial prophylaxis was the same between arms, and both groups received an antimetabolite for the first 6 months following LT. Patients were then followed at pre\u2010determined study intervals for the following year after LT. We administered the RAND\u201036SF survey to assess patient's health\u2010related quality of life at pre\u2010determined intervals. All analysis was performed with an intention to treat basis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We screened 194 consecutive patients and enrolled 110. Our control and study arms were well matched. Transplant characteristics were similar between groups. At all timepoints, both arms had similar serum creatinine and estimated glomerular filtration rate (eGFR), calculated by MDRD6 equation, with post\u2010transplant GFRs between 60 and 70\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>. Tacrolimus trough levels were similar between arms. The XRT arm had fewer AEs (166) and fewer serious AEs (70) compared to IRT (201 and 99, respectively). AEs most commonly were renal, infectious, or gastrointestinal in nature. While not statistically significant, XRT was held temporarily (25\u00a0vs. 35 cases) or discontinued (3\u00a0vs. 11 cases) less frequently than IRT and had fewer instances of rejection (7\u00a0vs. 12 cases).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This analysis showed that XRT is safe and effective as de novo maintenance IS in a steroid\u2010free protocol with RATG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15172","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T08:20:47Z","timestamp":1698481247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A report of a prospective randomized trial of extended\u2010release tacrolimus versus immediate release tacrolimus after liver transplantation with anti\u2010thymocyte induction in a steroid free 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