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We aimed to assess the benefit of gastric peroral endoscopic myotomy (G\u2010POEM) in persistent gastroparesis following PTx. This was a single center retrospective review of all patients who underwent G\u2010POEM for persistent gastroparesis following PTx. Patient demographics, pre and post procedure perception of symptom severity according to the patient assessment of upper gastrointestinal symptoms severity index (PAGI\u2010SYM), gastroparesis cardinal symptom index (GCSI) score, and 36\u2010item short form survey (SF36) score along with gastric emptying scintigraphy (GES) were analyzed. Seven PTx recipients underwent G\u2010POEM for persistent gastroparesis symptoms. The majority were female. All reported nausea\/vomiting, abdominal pain, bloating, and post prandial fullness prior to G\u2010POEM. The post procedure survey scores improved in all patients although this was not significant. The improvement in gastric emptying on GES was statistically significant. G\u2010POEM is a relatively new treatment option for gastroparesis. While it requires specialized proceduralist and training, we have documented improvement in the management of symptoms. With increasing experience, we anticipate more significant benefit in post PTx patients with persistent symptoms of gastroparesis undergoing G\u2010POEM.<\/jats:p>","DOI":"10.1111\/ctr.15176","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T17:11:59Z","timestamp":1699031519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of gastric peroral endoscopic myotomy (GPOEM) in chronic gastroparesis management after pancreas transplantation"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6385-6004","authenticated-orcid":false,"given":"Allison M.","family":"Drury","sequence":"first","affiliation":[{"name":"Department of Surgery Indiana University School of Medicine  Indianapolis Indiana 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