{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:53:59Z","timestamp":1787846039265,"version":"build-2784847793"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alcohol\u2010related liver disease (ALD) is the leading indication for liver transplantation worldwide. Since Mathurin et\u00a0al. described their experience in providing early liver transplantation for patients with ALD in 2011, other centers have followed suit with generally favorable survival outcomes. This patient population poses a unique clinical challenge given the expedited nature of the evaluation and the lack of any significant sobriety period prior to transplantation. The SALT (Sustained Alcohol Use Post\u2010Liver Transplant) score is a standardized psychometric tool increasingly used to help stratify the risk of relapse and guide listing decisions for these challenging clinical situations. In 2018, our center introduced a protocol for early liver transplantation for acute alcohol\u2010related hepatitis (AAH). In this article, we offer a retrospective review of 26 patients transplanted between May 2018 and May 2021, including at least 1\u2010year follow\u2010up, and compare outcomes to initial SALT scores; we further identify additional factors that may impact post\u2010transplant success. As transplant committees continue to weigh the ethical dilemma of denying lifesaving treatment against the obligation to remain stewards of a limited resource, we aim to contribute to a more nuanced understanding of risk regarding early transplantation for ALD.<\/jats:p>","DOI":"10.1111\/ctr.15194","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:51:16Z","timestamp":1700074276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Single\u2010center experience with early liver transplantation for acute alcohol\u2010related hepatitis\u2014Limitations of the SALT score and directions for future study"],"prefix":"10.1111","volume":"38","author":[{"given":"Ana","family":"Ivkovic","sequence":"first","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Center for Transplantation Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mladen","family":"Nisavic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Center for Transplantation Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Transplantation Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine Division of Gastroenterology and Hepatology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9242-7081","authenticated-orcid":false,"given":"Diana","family":"Punko","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Center for Transplantation Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley Elizabeth","family":"Aaron","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Surgical Immunology and Transplantation Eastern Carolina University  Greenville South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Keegan","sequence":"additional","affiliation":[{"name":"Center for Transplantation Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Social Service Department Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily D.","family":"Bethea","sequence":"additional","affiliation":[{"name":"Center for Transplantation Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Medicine Division of Gastroenterology and Hepatology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Yeh","sequence":"additional","affiliation":[{"name":"Center for Transplantation Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts 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to meet the challenge of addiction: psychobiology and clinical considerations","volume":"34","author":"Alim TN","year":"2012","journal-title":"Alcohol Res"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12841"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20109\u20108"}],"container-title":["Clinical 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