{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:12:08Z","timestamp":1785798728923,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Calcineurin inhibitor (CNI)\u2010induced nephrotoxicity (CNI\u2010T) is a post\u2010transplantation complication that leads to graft dysfunction. Older\u2010donor kidney grafts may be susceptible to chronic CNI exposure because of long\u2010term arteriolar damage. The primary aim of this study was to examine the CNI\u2010T incidence and time\u2010course changes in the graft function according to donor age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 334 kidney transplant recipients. CNI\u2010T was defined by Banff arteriolar hyaline thickening scores of \u22652 based on allograft protocol biopsy. Depending on donor age, participants were divided into the D\u00a0&gt;\u00a070 (\u226570 years), D60 (60\u201369 years), D50 (50\u201359 years), and D\u00a0&lt;\u00a049: (\u226449 years) groups. We investigated the extent to which CNI\u2010T affected the transplanted kidney function. Patients who did not develop CNI\u2010T during the study period were included in the non\u2010CNI\u2010T group; the remaining were grouped into the CNI\u2010T group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CNI\u2010T incidence was higher in donors aged &gt;50 years. Compared to D\u00a0&lt;\u00a049, the CNI\u2010T risk was 1.86 times higher in D50 and 2.9 times higher in D\u00a0&gt;\u00a070. Furthermore, the CNI\u2010T group exhibited a significantly lower graft function 10 years after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CNI\u2010T incidence increases in donors aged \u226550 years and affects renal function after 10 years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15196","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T17:38:23Z","timestamp":1700242703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Kidney donor age of 50 years or above is a risk factor for calcineurin inhibitor\u2010induced nephrotoxicity"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-897X","authenticated-orcid":false,"given":"Yusuke","family":"Takada","sequence":"first","affiliation":[{"name":"Department of Kidney Transplant Surgery and Urology Sapporo City General Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6167-9774","authenticated-orcid":false,"given":"Tatsu","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplant Surgery and Urology Sapporo City General Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7639-0912","authenticated-orcid":false,"given":"Hajime","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplant Surgery and Urology Sapporo City General Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Sapporo City General Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8080-5962","authenticated-orcid":false,"given":"Kiyohiko","family":"Hotta","sequence":"additional","affiliation":[{"name":"Department of Urology Hokkaido University Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6537-376X","authenticated-orcid":false,"given":"Kazufumi","family":"Okada","sequence":"additional","affiliation":[{"name":"Data Science Center Promotion Unit Institute of Health Science Innovation for Medical Care Hokkaido University Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Shiono","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplant Surgery and Urology Sapporo City General Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplant Surgery and Urology Sapporo City General Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplant Surgery and Urology Sapporo City General Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5121-6686","authenticated-orcid":false,"given":"Hiroshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplant Surgery and Urology Sapporo City General Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12696"},{"key":"e_1_2_10_3_1","unstructured":"ProcurementO NetworkT.OPTN: Organ procurement and transplantation network. Accessed March 13 2023.https:\/\/optn.transplant.hrsa.gov\/"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04800908"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03465.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S149340"},{"key":"e_1_2_10_7_1","first-page":"9","volume-title":"Guidelines on TDM of Immunosuppressive Drugs in Organ Transplantation 2018","author":"Japanese Society of Therapeutic Drug Monitoring, Japanese Society of Transplantation","year":"2018"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002366"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00332.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.924235"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03820609"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxaa032"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2008.09.002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2015.10.001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60699-5"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31824ad60a"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12076"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T08:33:24Z","timestamp":1741768404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,17]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/ctr.15196"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15196","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,17]]},"assertion":[{"value":"2023-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15196"}}