{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:53:56Z","timestamp":1762869236584,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The risk factors and outcomes associated with post\u2010 transplant hypotension after simultaneous pancreas and kidney (SPK) Transplantation are poorly defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SPK recipients at our center between 2010 and 2021 with functioning pancreas and kidney grafts for &gt;6 months were included. Recipients were then divided into three groups based on active medications for the treatment of hypo\u2010or hypertension at 6\u2010months post\u2010transplant: those with normal blood pressure (NBP) not requiring medication (NBP group), those on antihypertensive medications (HTN group), and those on medications for hypotension (fludrocortisone and\/or midodrine) (Hypotensive group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 306 recipients were included in the study: 54 (18%) in the NBP group, 215 (70%) in the HTN group, and 37 (12%) in the Hypotensive group. On multivariate analysis, the use of T\u2010depleting induction (aHR\u00a0=\u00a09.64, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0001, 95% Cl\u00a0=\u00a03.12\u201329.75), pre\u2010transplant use of hypotensive medications (aHR\u00a0=\u00a04.53, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0003, 95% Cl\u00a0=\u00a01.98\u201310.38), and longer duration of dialysis (aHR\u00a0=\u00a01.02, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01, 95% Cl\u00a0=\u00a01.00\u20131.04) were associated with an increased risk of post\u2010transplant hypotension. Post\u2010transplant hypotension was not associated with an increased risk of death\u2010censored kidney or pancreatic allograft failure, or patient death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypotension was common even 6 months post\u2010SPK transplantation. With appropriate management, hypotension was not associated with detrimental graft or patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15197","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:04:14Z","timestamp":1700244254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk factors and outcomes of persistent post\u2010transplant hypotension among simultaneous pancreas and kidney transplant recipients"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8230-3889","authenticated-orcid":false,"given":"Fahad","family":"Aziz","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Nephrology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-8583","authenticated-orcid":false,"given":"Didier","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6088-9727","authenticated-orcid":false,"given":"Margaret","family":"Jorgenson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Wisconsin Hospital and Clinics  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0175-6825","authenticated-orcid":false,"given":"Brenda","family":"Muth","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Baltaji","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Pantha","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dixon","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Odorico","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7465","authenticated-orcid":false,"given":"Sandesh","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20101580"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13562"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.6.1366"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.1998.tb00981.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.7.802"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7574628"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0041\u20101345(97)01288\u20108"},{"issue":"2","key":"e_1_2_8_9_1","first-page":"127","article-title":"Orthostatic hypotension in kidney pancreas transplant patients and its relation to preexisting autonomic neuropathy","volume":"6","author":"Khurana A","year":"2008","journal-title":"Exp Clin Transplant"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399\u20100012.2000.140108.x"},{"key":"e_1_2_8_11_1","unstructured":"CommittePT.Definition of Pancreas Graft Failure.2023. 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