{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:48:17Z","timestamp":1778640497303,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>New estimated glomerular filtration rate (eGFR) equations using serum creatinine and\/or cystatin C have been derived to eliminate adjustment by perceived Black ancestry. We sought to analyze the performance of newer eGFR equations among Black living kidney donor candidates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Black candidates (<jats:italic>n<\/jats:italic>\u00a0=\u00a064) who had measured iothalamate GFR between January 2015 and October 2021 were included, and eGFR was calculated using race adjusted (eGFRcr2009 and eGFRcr\u2010cys2012) and race unadjusted (eGFRcys2012, eGFRcr2021, and eGFRcr\u2010cys2021) CKD\u2010EPI equations. Bias and accuracy were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The eGFRcr2021 equation had a negative bias of 9\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup>, while other equations showed a modest positive bias. Accuracy within 10% and 30% was greatest using the eGFRcr\u2010cys2021 equation. With the eGFRcr2021 equation, 9.4% of donors with an mGFR\u00a0&gt;\u00a080\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup> were misclassified as having an eGFR\u00a0&lt;\u00a080 mL\/min\/1.73 m<jats:sup>2<\/jats:sup>. eGFR was also compared among 18 kidney donors at 6\u201324 months post\u2010donation. Post\u2010donation, the percentage of donors with an eGFR\u00a0&lt;\u00a060\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup> was 44% using the eGFRcr2021 equation compared to 11% using the eGFRcr\u2010cys2021 equation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The CKD\u2010EPICr2021 equation appears to underestimate true GFR in Black living donor candidates. Alternatively, compared to CKD\u2010EPICr2021, the CKD\u2010EPICr\u2010CysC2021 equation appears to perform with less bias and improved accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15198","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:39:16Z","timestamp":1700073556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Performance of estimated glomerular filtration rate equations in Black living kidney donor candidates"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8625-9288","authenticated-orcid":false,"given":"Joshua J.","family":"Augustine","sequence":"first","affiliation":[{"name":"Department of Nephrology Glickman Urological and Kidney Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimen","family":"Liaqat","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Arrigain","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse D.","family":"Schold","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Department of Epidemiology Colorado School of Public Health University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio D.","family":"Poggio","sequence":"additional","affiliation":[{"name":"Department of Nephrology Glickman Urological and Kidney Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021070988"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953"},{"key":"e_1_2_12_4_1","unstructured":"Organ Procurement & Transplantation Network Policy 14: Living Donation. Accessed December 10 2022.https:\/\/optn.transplant.hrsa.gov\/media\/eavh5bf3\/optn_policies.pdf"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002797"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001770"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0003052021"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200011150-00016"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000918"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14136"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0270827","article-title":"Impact of measured versus estimated glomerular filtration rate\u2010based screening on living kidney donor characteristics: a study of multiple cohorts","volume":"17","author":"Weijden J","year":"2022","journal-title":"PLoS One"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90488-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1973.127"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2022.100558"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab042"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02110213"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.4410"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03040410"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001143"},{"key":"e_1_2_12_20_1","unstructured":"Organ Procurement & Transplantation Network National Data.https:\/\/optn.transplant.hrsa.gov\/data\/view\u2010data\u2010reports\/national\u2010data\/#"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510491"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T08:33:39Z","timestamp":1741768419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,15]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/ctr.15198"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15198","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,15]]},"assertion":[{"value":"2023-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15198"}}