{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:32:00Z","timestamp":1791916320594,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Donor\u2010derived endemic mycoses are infrequently reported. We summarized the clinical characteristics and outcomes of these infections to provide guidance to transplant clinicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multiple databases were reviewed from inception through May 31, 2023 using endemic fungi as key words (e.g., Coccidioides, histoplasma, blastomyces, talaromyces, paracoccidioides). Only donor\u2010derived infections (DDI) were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four cases of DDI were identified from 18 published reports; these included 16 coccidioidomycosis, seven histoplasmosis, and one talaromycosis. No cases of blastomycosis and paracoccidiodomycosis were published. The majority were male (17\/24,70.8%). Half of the cases were probable (12\/24, 50%), seven were possible (29.2%), and only five were proven DDI (20.8%). Donor\u2010derived coccidioidomycosis were observed in kidney (<jats:italic>n<\/jats:italic>\u00a0=\u00a011), lung (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), liver (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), heart (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) and combined SOT recipients (1 KP, 1 KL) at a median time of .9 (range .2\u201335) months after transplantation. For histoplasmosis, the majority were kidney recipients (6 of 7 cases) at a median onset of 8 (range .4\u201348) months after transplantation. The single reported possible donor\u2010derived talaromycosis occurred in a man whose organ donor had at\u2010risk travel to Southeast Asia. Collectively, the majority of donors had high\u2010risk exposure to <jats:italic>Coccidioides<\/jats:italic> (9\/11) or <jats:italic>Histoplasma<\/jats:italic> sp. (6\/6). Most donor\u2010derived endemic mycoses were disseminated (18\/24, 75%), and mortality was reported in almost half of recipients (11\/24, 45.8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Donor\u2010derived endemic mycoses are often disseminated and are associated with high mortality. A detailed evaluation of donors for the potential of an undiagnosed fungal infection prior to organ donation is essential to mitigate the risk of these devastating infections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15199","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:14:19Z","timestamp":1700784859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Donor\u2010derived endemic mycoses after solid organ transplantation: A review of reported cases"],"prefix":"10.1111","volume":"38","author":[{"given":"Cybele Lara R.","family":"Abad","sequence":"first","affiliation":[{"name":"Department of Medicine Section of Infectious Diseases Philippine General Hospital University of the Philippines Manila  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymund R.","family":"Razonable","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases and The William J Von Liebig Center for Transplantation and Clinical Regeneration Mayo Clinic College of Medicine and Sciences  Rochester Minnesota 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