{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:31Z","timestamp":1753878451762,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) in patients\u00a0&lt;3 years of age remains controversial. Data on haploidentical donor (HID) transplants in this age group is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>We retrospectively analyzed the prognosis of 97 patients with acute leukemia aged\u00a0&lt;3 years who underwent HID transplantation at our institute.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a median follow\u2010up of 45 months, the 3\u2010year disease\u2010free survival (DFS), overall survival (OS), and 3\u2010year cumulative incidence rate of treatment\u2010related mortality were 69.3% (95% confidence interval (CI): 59.9%\u201378.7%), 74.2% (95% CI: 65.2%\u201383.2%), and 3.6% (95% CI: 0.9%\u20139.7%) in all 97 patients, respectively. The 3\u2010year DFS and OS rate in patients diagnosed\u00a0&lt;1 year and patients diagnosed \u22651 year were comparable: 77.8% (95% CI: 62.2%\u201393.4%) versus 66.3% (95% CI: 55.0%\u201377.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.253) and 82.5% (95% CI: 66.3\u201398.7%) versus 72.8% (95% CI: 61.9%\u201383.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.153), respectively. At the last follow\u2010up, 23 patients had died, and 20 had died of relapse. Multivariate analysis revealed that positive pre\u2010HSCT flow cytometric minimal residual disease (hazard ratio 5.605, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.000) and AML\u2010M7 expression (hazard ratio 2.906, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.014) were independent adverse prognostic variables for relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HID transplantation is potent and safe for infants and young patients with acute leukemia. Relapse is the primary cause of treatment failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15247","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:29:48Z","timestamp":1708428588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The prognosis of haploidentical hematopoietic stem cell transplantation in infants and patients under 3 years old with acute leukemia"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0435-9913","authenticated-orcid":false,"given":"Guan\u2010hua","family":"Hu","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking\u2010Tsinghua Center for Life Science Research Unit of Key Technique for Diagnosis and Treatment of Hematologic Malignancies Chinese Academic of Medical Sciences  Beijing China"},{"name":"Department of Pediatrics Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-6792","authenticated-orcid":false,"given":"Xiao\u2010hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking\u2010Tsinghua Center for Life Science Research Unit of Key Technique for Diagnosis and Treatment of Hematologic Malignancies Chinese Academic of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking\u2010Tsinghua Center for Life Science Research Unit of Key Technique for Diagnosis and Treatment of Hematologic Malignancies Chinese Academic of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-1081","authenticated-orcid":false,"given":"Lan\u2010ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking\u2010Tsinghua Center for Life Science Research Unit of Key Technique for Diagnosis and Treatment of Hematologic Malignancies Chinese Academic of Medical Sciences  Beijing 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