{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:12Z","timestamp":1753878612859,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There is a lack of data regarding the peri\u2010operative and long\u2010term outcomes of kidney transplantation in cystic fibrosis (CF) patients. Herein, we report the peri\u2010operative and long\u2010term outcomes of kidney transplantation in CF patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>All CF patients who received a kidney transplant at the national kidney transplant center between 1993 and 2022 were identified. Recipients of the contralateral donor kidney were selected as a control group. Primary outcomes included 1\u2010, 5\u2010, and 10\u2010 year death\u2010censored graft survival and overall survival. Secondary outcomes included peri\u2010operative morbidity, acute graft rejection, delayed graft function (DGF), and length of stay (LOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen patients received a kidney transplant over the study period. Median age at transplantation was 35 (IQR 31, 40) years. The 1\u2010, 5\u2010, and 10\u2010year death\u2010censored graft survival was 92, 74, and 74% in the CF group compared to 100, 92, and 92% in the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.44). The 1\u2010, 5\u2010, and 10\u2010year overall survival in the CF group was 85, 66, and 57% compared to 100, 92, and 82% in the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.036). There was no significant difference in peri\u2010operative outcomes including LOS (10\u00a0vs. 11 days, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.84), ICU admission (1\u00a0vs. 0 patients, <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.99), acute rejection episodes (2\u00a0vs. 1 patients, <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.99), and DGF (1\u00a0vs. 2 patients, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.60).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CF patients have good long\u2010term graft survival, however, overall survival was worse compared to a matched cohort. These data provide important information for transplant surgeons when considering suitable donor allografts in this unique patient population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15255","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T09:09:20Z","timestamp":1708765760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peri\u2010operative and long\u2010term outcomes of kidney transplantation in patients with cystic fibrosis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0126-8300","authenticated-orcid":false,"given":"John A.","family":"O'Kelly","sequence":"first","affiliation":[{"name":"Department of Transplant Urology and Nephrology Beaumont Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatimah","family":"Alaya","sequence":"additional","affiliation":[{"name":"Department of Transplant Urology and Nephrology Beaumont Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-1475","authenticated-orcid":false,"given":"Niall F.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Transplant Urology and Nephrology Beaumont Hospital  Dublin Ireland"},{"name":"Department of Surgery Royal College of Surgeons in Ireland  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilly","family":"Little","sequence":"additional","affiliation":[{"name":"Department of Transplant Urology and Nephrology Beaumont Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ponnusamy","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Transplant Urology and Nephrology Beaumont Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(13)70025-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2013.03.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16597"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/frtra.2022.992985"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6183969"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14112748"},{"issue":"4","key":"e_1_2_10_8_1","first-page":"620","article-title":"Cumulative immunosuppressant exposure is associated with diversified cancer risk among 14 832 patients with systemic lupus erythematosus: a nested case\u2010control study","volume":"56","author":"Hsu CY","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-02139-4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2020.0744"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14371"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T17:56:02Z","timestamp":1711734962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/ctr.15255"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15255","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15255"}}