{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:55:05Z","timestamp":1787846105633,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Guidelines recommend kidney transplant alone (KTA) in compensated cirrhosis based on a few small studies, but this is not widely performed despite its potential benefit to patients and the organ supply. Our aim was to determine the outcomes of KTA in patients with compensated cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>From 1\/2012 to 12\/2021, outcomes in KTA recipients with compensated cirrhosis were retrospectively compared to patients with chronic liver disease (CLD) but no cirrhosis. Patients with compensated cirrhosis were also compared to a matched cohort (based on age, time on hemodialysis, sex, and ethnicity) of KTA recipients without CLD. The outcomes included patient survival, allograft failure, allograft rejection, serious infection, liver decompensation, and length of stay (LOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 9 years, 1562 KTAs were performed, with 150 (9.6%) patients having CLD mostly due to chronic hepatitis C, and a median follow\u2010up of 3.5 years. 32\/150 (21%) had compensated cirrhosis at the time of KTA with a mean MELD\u2010Na of 22 (1.5). Matched controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a0189) were identified. We found no differences in patient survival (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.07), allograft failure (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.6), allograft rejection (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.43), rates of serious infection (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.31), as well as LOS (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.61) among patients with compensated cirrhosis compared to patients with CLD but no cirrhosis, but with higher rates of liver decompensation (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). Similarly, compared to patients without CLD, patients with cirrhosis had similar rates of patient survival (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.20), allograft failure (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.27), allograft rejection (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.62) and LOS (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.19) but with higher rates of serious infections (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study supports the safety and efficacy of KTA in patients with compensated cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15259","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T12:01:35Z","timestamp":1708430495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes after kidney transplant alone in patients with cirrhosis\u2014A case\u2010control study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9891-1050","authenticated-orcid":false,"given":"Rohit R.","family":"Nathani","sequence":"first","affiliation":[{"name":"Department of Medicine Mount Sinai Morningside and West  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Rutledge","sequence":"additional","affiliation":[{"name":"Recanati\/Miller Transplantation Institute Division of Liver Diseases Department of Medicine Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina S.","family":"Villarroel","sequence":"additional","affiliation":[{"name":"Department of Medicine Mount Sinai Beth Israel  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Recanati\/Miller Transplantation Institute Division of Abdominal Transplantation Department of Surgery Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1635-9136","authenticated-orcid":false,"given":"Sander S.","family":"Florman","sequence":"additional","affiliation":[{"name":"Recanati\/Miller Transplantation Institute Division of Abdominal Transplantation Department of Surgery Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2695-9570","authenticated-orcid":false,"given":"Fasika M.","family":"Tedla","sequence":"additional","affiliation":[{"name":"Recanati\/Miller Transplantation Institute Division of Liver Diseases Department of Medicine Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Schiano","sequence":"additional","affiliation":[{"name":"Recanati\/Miller Transplantation Institute Division of Liver Diseases Department of Medicine Icahn School of Medicine at Mount Sinai  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene Y.","family":"Im","sequence":"additional","affiliation":[{"name":"Recanati\/Miller Transplantation Institute Division of Liver Diseases Department of Medicine Icahn School of Medicine at Mount Sinai  New York 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