{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:58:15Z","timestamp":1778605095842,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hyperparathyroidism (HPT) can contribute to metabolic bone disease following kidney transplantation. We evaluated post\u2010transplant trends in intact parathyroid hormone (iPTH) and determined predictors of HPT in pediatric kidney transplant (KTx) recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010center study, retrospective data were collected on 88 children from 2013 to 2019. Data collected included dialysis vintage, biochemical parameters, post\u2010transplant trends in iPTH, 25(OH)Vitamin D levels and estimated glomerular filtration rate (eGFR ml\/min\/1.73 m<jats:sup>2<\/jats:sup>). Pre\u2010transplant treatment for HPT was quantified with a Treatment Burden score (TB, score range: 0\u2010100). After log\u2010transforming skewed variables (iPTH and eGFR), multivariable linear regression was performed to determine predictors of log {iPTH} at 6 and 36 months (mo) post\u2010transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 12.8 (range: 1.9\u201020.5) years, and dialysis vintage was 11.2 (range:\u00a00.0\u2010112.9) months. The majority were of Hispanic and African Ancestry (77.3%). Median post\u2010transplant iPTH was 69.5 (range: 1.8\u2010306.8) pg\/ml at 6\u00a0mo with a gradual downward trend to 59.0 (range: 28.0\u2010445.0) pg\/ml at 36\u00a0mo. Significant multivariable predictors of higher log {iPTH} post\u2010transplant included longer dialysis vintage, higher TB, and lower log{eGFR} at 6\u00a0mo, and higher TB, lower log{eGFR}, and deceased donor transplant at 36\u00a0mo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recognition of risk factors for HPT and monitoring iPTH post\u2010transplant may facilitate timely interventions to mitigate cardiovascular and bone disease in pediatric KTx recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Message<\/jats:title><jats:p><jats:list>\n<jats:list-item><jats:p>Describe serial trends in intact PTH after kidney transplantation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pre\u2010 and post\u2010transplant factors that contribute to persistence or re\u2010occurrence of hyperparathyroidism after kidney transplantation in children include longer dialysis vintage, high pre\u2010transplant treatment burden and decreased post\u2010transplant GFR.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Recognition of these factors, and monitoring intact PTH after kidney transplantation, could facilitate timely interventions to mitigate cardiovascular and bone disease in children.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15284","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T14:43:42Z","timestamp":1710427422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Determinants of hyperparathyroidism in children after kidney transplantation"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0865-3279","authenticated-orcid":false,"given":"Wendy","family":"Glaberson","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Nephrology University of Miami Miller School of Medicine (and the Miami Transplant Institute) 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