{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:09:14Z","timestamp":1791929354831,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about the relationship between cytomegalovirus (CMV) infections and donor\u2010derived cell\u2010free DNA (dd\u2010cfDNA) in heart transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In our study, CMV and dd\u2010cfDNA results were prospectively collected on single\u2010organ heart transplant recipients. If the CMV study was positive, a CMV study with dd\u2010cfDNA was repeated 1\u20103 months later. The primary aim was to compare dd\u2010cfDNA between patients with positive and negative CMV results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 44 patients enrolled between August 2022 and April 2023, 12 tested positive for CMV infections, 25 were included as controls, and seven patients with a viral infection without CMV were excluded. Baseline characteristics did not differ significantly between CMV\u2010positive and CMV\u2010negative patients with the exception of a later median time post\u2010transplant in the CMV\u2010positive group (253 days vs. 120 days, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03). Dd\u2010cfDNA levels were significantly higher in patients with CMV infections compared to those without (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) with more patients in the CMV positive group showing dd\u2010cfDNA results \u2265.12% (75%\u00a0vs. 8%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and \u2265.20% (58%\u00a0vs. 8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002). Each 1 log<jats:sub>10<\/jats:sub> copy\/ml reduction in CMV viral load from visit 1 to visit 2 was associated with a.23% reduction in log<jats:sub>10<\/jats:sub> dd\u2010cfDNA (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that active CMV infections may raise dd\u2010cfDNA levels in patients following heart transplantation. Larger studies are needed to validate these preliminary findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15287","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T09:24:51Z","timestamp":1710321891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The impact of active cytomegalovirus infection on donor\u2010derived cell\u2010free DNA testing in heart transplant recipients"],"prefix":"10.1111","volume":"38","author":[{"given":"Amit H.","family":"Alam","sequence":"first","affiliation":[{"name":"Division of Cardiology New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-9214","authenticated-orcid":false,"given":"Johanna","family":"Van Zyl","sequence":"additional","affiliation":[{"name":"Texas A&amp;M University Health Science Center College of Medicine  Dallas Texas USA"},{"name":"Baylor Scott &amp; White Research Institute Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira I.","family":"Shakoor","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Research Institute Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Farsakh","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Research Institute Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad B.","family":"Abdelrehim","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Research Institute Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville","family":"Maliakkal","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Research Institute Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9471-3383","authenticated-orcid":false,"given":"Aayla K.","family":"Jamil","sequence":"additional","affiliation":[{"name":"Texas A&amp;M University Health Science Center College of Medicine  Dallas Texas USA"},{"name":"Baylor Scott &amp; White Research Institute Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raksha","family":"Patel","sequence":"additional","affiliation":[{"name":"Center for Advanced Heart and Lung Disease Baylor University Medical Center Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7200-8755","authenticated-orcid":false,"given":"Joost","family":"Felius","sequence":"additional","affiliation":[{"name":"Texas A&amp;M University Health Science Center College of Medicine  Dallas Texas USA"},{"name":"Baylor Scott &amp; White Research Institute Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staci","family":"McKean","sequence":"additional","affiliation":[{"name":"Center for Advanced Heart and Lung Disease Baylor University Medical Center Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4894-396X","authenticated-orcid":false,"given":"Shelley A.","family":"Hall","sequence":"additional","affiliation":[{"name":"Texas A&amp;M University Health Science Center College of Medicine  Dallas Texas USA"},{"name":"Center for Advanced Heart and Lung Disease Baylor University Medical Center Baylor Scott &amp; White Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.11.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.049098"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/pcc.0000000000000397"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.36628\/ijhf.2021.0042"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010013\u20100131\u20109"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1959"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/mot.0000000000000636"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2022.02.027"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15339"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.12.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.04.009"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.05.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.01.451"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1906320116"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14549"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.11.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.01.276"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103062.2009.00372.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000001095"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.10.015"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2021.03.013"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.02.008"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T16:51:49Z","timestamp":1711385509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/ctr.15287"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15287","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2024-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15287"}}