{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T18:43:20Z","timestamp":1772909000949,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies suggest the transplantation of Hepatitis C (HCV) hearts from viremic donors is associated with comparable 1 year survival to nonviremic donors. Though HCV viremia is a known risk factor for accelerated atherosclerosis, data on cardiac allograft vasculopathy (CAV) outcomes are limited. We compared the incidence of CAV in heart transplant recipients from HCV viremic donors (nucleic acid amplification test positive; NAT+) compared to non\u2010HCV infected donors (NAT\u2212).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed annual coronary angiograms with intravascular ultrasound from April 2017 to August 2020 at two large cardiac transplant centers. CAV was graded according to ISHLT guidelines. Maximal intimal thickness (MIT) \u2265 0.5\u00a0mm was considered significant for subclinical disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 270 heart transplant recipients (mean age 54; 77% male), 62 patients were transplanted from NAT+ donors. CAV \u2265 grade 1 was present in 8.8% of the NAT+ versus 16.8% of the NAT\u2010 group at 1 year, 20%\u00a0versus 28.8% at 2 years, and 33.3%\u00a0versus 41.5% at 3 years. After adjusting for donor age, donor smoking history, recipient BMI, recipient, hypertension, and recipient diabetes, NAT+ status did not confer increased risk of CAV (HR.80; 95% CI.45\u20131.40, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.43) or subclinical IVUS disease (HR.87; 95% CI.58\u20131.30, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.49). Additionally, there was no difference in the presence of rapidly progressive lesions on IVUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data show that NAT+ donors conferred no increased risk for early CAV or subclinical IVUS disease following transplantation in a cohort of heart transplant patients who were treated for HCV, suggesting the short\u2010term safety of this strategy to maximize the pool of available donor hearts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15294","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T10:18:40Z","timestamp":1711621120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac allograft vasculopathy in heart transplant recipients from hepatitis C viremic donors"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2069-1534","authenticated-orcid":false,"given":"Bernard S.","family":"Kadosh","sequence":"first","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoinette S.","family":"Birs","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Flattery","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxine","family":"Stachel","sequence":"additional","affiliation":[{"name":"Leon H. 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Charney Division of Cardiology NYU Langone Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4051-5629","authenticated-orcid":false,"given":"Saima","family":"Aslam","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louai","family":"Razzouk","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tajinderpal","family":"Saraon","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randal","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology NYU Langone Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaline","family":"Rao","sequence":"additional","affiliation":[{"name":"Leon H. 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