{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:33:06Z","timestamp":1784287986582,"version":"3.55.0"},"reference-count":91,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Solid organ transplantation (SOT) is a lifesaving treatment for end\u2010stage organ failure. Although many factors affect the success of organ transplantation, recipient and donor sex are important biological factors influencing transplant outcome. However, the impact of the four possible recipient and donor sex combinations (RDSC) on transplant outcome remains largely unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A scoping review was carried out focusing on studies examining the association between RDSC and outcomes (mortality, graft rejection, and infection) after heart, lung, liver, and kidney transplantation. All studies up to February 2023 were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple studies published between 1998 and 2022 show that RDSC is an important factor affecting the outcome after organ transplantation. Male recipients of SOT have a higher risk of mortality and graft failure than female recipients. Differences regarding the causes of death are observed. Female recipients on the other hand are more susceptible to infections after SOT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Differences in underlying illnesses as well as age, immunosuppressive therapy and underlying biological mechanisms among male and female SOT recipients affect the post\u2010transplant outcome. However, the precise mechanisms influencing the interaction between RDSC and post\u2010transplant outcome remain largely unclear. A better understanding of how to identify and modulate these factors may improve outcome, which is particularly important in light of the worldwide organ shortage. An analysis for differences of etiology and causes of graft loss or mortality, respectively, is warranted across the RDSC groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Practitioner points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Recipient and donor sex combinations affect outcome after solid organ transplantation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>While female recipients are more susceptible to infections after solid organ transplantation, they have higher overall survival following SOT, with causes of death differing from male recipients.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Sex\u2010differences should be taken into account in the post\u2010transplant management.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15312","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T17:28:00Z","timestamp":1714325280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4570-949X","authenticated-orcid":false,"given":"Christian Tibor Josef","family":"Magyar","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0447-9527","authenticated-orcid":false,"given":"Charlene Pierrine","family":"Gretener","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Baldi","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Storni","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2237-9432","authenticated-orcid":false,"given":"Corina","family":"Kim\u2010Fuchs","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9924-1749","authenticated-orcid":false,"given":"Daniel","family":"Candinas","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4562-9016","authenticated-orcid":false,"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6043-7910","authenticated-orcid":false,"given":"Matthias","family":"Knecht","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-3807","authenticated-orcid":false,"given":"Guido","family":"Beldi","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-912X","authenticated-orcid":false,"given":"C\u00e9dric","family":"Hirzel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-5936","authenticated-orcid":false,"given":"Daniel","family":"Sidler","sequence":"additional","affiliation":[{"name":"Department for Nephrology and Hypertension University Hospital Insel Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Reineke","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Inselspital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4887-5776","authenticated-orcid":false,"given":"Vanessa","family":"Banz","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2022.12.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-023-00998-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00538-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70049-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.513"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/599790"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321060111"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01269"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005374"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.90"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233521"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2022.04.011"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2017.02.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-014-0213-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544100-00006"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj060428"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genm.2011.01.003"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.02.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13737"},{"issue":"1","key":"e_1_2_10_21_1","first-page":"29","article-title":"Gender does matter: gender\u2010specific outcome analysis of 67,855 heart transplants","volume":"61","author":"Kaczmarek I","year":"2013","journal-title":"Thorac Cardiovasc Surg"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)01105-3"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.108.844183"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14804"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCN.0b013e31822ce6c9"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2017.04.004"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-77932-4_24"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2021.01.001"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2007.10.007"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492338"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.01.022"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214048"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07660716"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1608-x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004109"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2016.04.222"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-020-01859-3"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2012.00744.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13981"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2005.00327.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S356543"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.01.178"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.4149\/BLL_2022_074"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2021.101490"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2006.00519.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11511017"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14510"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003542"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.103933"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2022.10263"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13673"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i20.2203"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.40"},{"issue":"2","key":"e_1_2_10_54_1","first-page":"184","article-title":"Gender matches in liver transplant allocation: matched and mismatched male\u2010female donor\u2010recipient combinations; long\u2010term follow\u2010up of more than 2000 patients at a single center","volume":"14","author":"Schoening WN","year":"2016","journal-title":"Exp Clin Transplant"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21946"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03384.x"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13152"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2020.19286"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-018-3333-4"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-018-1672-3"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14608"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001192"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20714"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2021.09.023"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs570"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.08.122"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.02.007"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.08.101"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu340"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.01.012"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002888"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.09.020"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01900-y"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.09.015"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14064"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.02.083"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.11.001"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01512-2018"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12964"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101536"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2013.0031"},{"issue":"7","key":"e_1_2_10_83_1","first-page":"1","article-title":"Ethnic disparities attributed to the manifestation in and response to type 2 diabetes: insights from metabolomics","volume":"18","author":"Vasishta S","year":"2022","journal-title":"Metabolomics 2022 187"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003960"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i22.3537"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005635"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2020.1455"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-014-2639-3"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016121380"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002915"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.08.083"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13671"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T08:04:37Z","timestamp":1716537877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,28]]},"references-count":91,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/ctr.15312"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15312","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,28]]},"assertion":[{"value":"2023-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15312"}}