{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:28:08Z","timestamp":1753878488545,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pediatric Heart\u2010lung transplant (HLTX) is performed for endstage congenital heart disease (CHD) with irreversible pulmonary hypertension or non\u2010congenital heart disease (NCHD) with end\u2010stage heart and lung disease. CHD could influence the outcomes of HTLX due to increased complexity of the operation as compared to NCHD. In this study we evaluated the influence of cardiac diagnosis on outcomes of pediatric HTLX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The UNOS database (1987\u20132022) was queried for primary HTLX in patients &lt;18\u00a0years. The data were extracted for demographics, pretransplant characteristics, post\u2010transplant outcomes, and analyzed for the impact of cardiac diagnosis on post\u2010transplant outcomes. Standard statistical tests were used. Survival was compared using the Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety of the 213 patients who underwent HLTX had CHD. There were no demographic differences. Heart listing status was similar but with a higher LAS score for NCHD. NCHD had higher pre\u2010operative life support use (mechanical ventilation, inotropes or dialysis) but the use of ECMO as a bridge to transplantation was similar. Wait\u2010list times were longer for CHD. The ischemic times were similar. Post\u2010transplant dialysis, stroke, prolonged mechanical ventilation, and rejection were similar. Survival at 30\u2010days, 1\u2010year, and long\u2010term survival at 17\u00a0years was similar. Non\u2010survivors at 30\u2010days post\u2010transplant were on life support, used ECMO as a bridge, had lower wait\u2010list times, longer ischemic times and had strokes. Non\u2010survivors at 1\u2010year had similar factors in addition to a higher dialysis use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cardiac diagnosis had no impact on outcomes after Pediatric HLTX. Patients on life support or ECMO before transplantation were transplanted faster but with lower survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15318","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T05:49:58Z","timestamp":1713419398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of cardiac diagnosis on outcomes of pediatric heart\u2010lung transplantation"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-8364","authenticated-orcid":false,"given":"Sandeep","family":"Sainathan","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic Surgery University of Miami  Miami USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University of Pittsburgh  Pittsburgh USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Mullinari","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery University of Miami  Miami USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3607-0345","authenticated-orcid":false,"given":"Pablo","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University of Pittsburgh  Pittsburgh USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.05.049"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/02184923231151551"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(94)70373-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.01.023"},{"issue":"10","key":"e_1_2_7_6_1","first-page":"989","article-title":"Pediatric heart\u2010lung transplants age distribution by era of transplant. UNOS slide","volume":"32","year":"2013","journal-title":"JHLT"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072\u20101439.2014.07.05"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.049502"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0003\u20104975(01)03099\u20105"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.08.005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.08.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.01.1226"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2019.06.061"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102017\u2010311876"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.03.110"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(03)00305-X"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T11:12:35Z","timestamp":1713784355000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/ctr.15318"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15318","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15318"}}