{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:01:35Z","timestamp":1792839695776,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/aims<\/jats:title><jats:p>Direct\u2010acting antiviral (DAA) therapy has revolutionized solid organ transplantation by providing an opportunity to utilize organs from HCV\u2010viremic donors. Though transplantation of HCV\u2010viremic donor organs into aviremic recipients is safe in the short term, midterm data on survival and post\u2010transplant complications is lacking. We provide a midterm assessment of complications of lung transplantation (LT) up to 2 years post\u2010transplant, including patient and graft survival between HCV\u2010viremic transplantation (D+) and HCV\u2010aviremic transplantation (D\u2010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective cohort study including 500 patients from 2018 to 2022 who underwent LT at our quaternary care institution. Outcomes of patients receiving D+ grafts were compared to those receiving D\u2010 grafts. Recipients of HCV antibody+ but PCR\u2010 grafts were treated as D\u2010 recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 470 D\u2010 and 30 D+ patients meeting inclusion criteria. Crude mortality did not differ between groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.43). Patient survival at years 1 and 2 did not differ between D+ and D\u2010 patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.89, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.87, respectively), and graft survival at years 1 and 2 did not differ between the two groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.90, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.88, respectively). No extrahepatic manifestations or fibrosing cholestatic hepatitis (FCH) occurred among D+ recipients. D+ and D\u2010 patients had similar rates of post\u2010transplant chronic lung allograft rejection (CLAD) (<jats:italic>p<\/jats:italic>\u00a0=\u00a06.7%\u00a0vs. 12.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.3), acute cellular rejection (60.0%\u00a0vs. 58.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.8) and antibody\u2010mediated rejection (16.7%\u00a0vs. 14.2%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is no difference in midterm patient or graft survival between D+ and D\u2010LT. No extrahepatic manifestations of HCV occurred. No differences in any type of rejection including CLAD were observed, though follow\u2010up for CLAD was limited. These results provide additional support for the use of HCV\u2010viremic organs in selected recipients in LT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15325","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T10:28:28Z","timestamp":1715164108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hepatitis C viremic lung transplantation to aviremic recipients: Comprehensive outcomes and post\u2010transplant viremia"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-9176","authenticated-orcid":false,"given":"Sarah","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritika","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar T","family":"Sims","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Gastroenterology, Hepatology, and Nutrition Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Budev","sequence":"additional","affiliation":[{"name":"Respiratory Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"United network for organ sharing","year":"2023"},{"key":"e_1_2_8_3_1","article-title":"Predictors of deceased donor lung utilization in the United States","author":"Edwards L","year":"2015","journal-title":"Am J Transplant"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15678"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.08.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.01.243"},{"key":"e_1_2_8_7_1","volume-title":"Treatment of HCV\u2010uninfected transplant recipients receiving organs from HCV\u2010viremic donors","author":"American Association for the Study of Liver 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Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T08:03:28Z","timestamp":1716537808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/ctr.15325"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15325","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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