{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:18Z","timestamp":1753878378987,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients undergoing heart transplants are at risk of rejection which can have significant morbidity and mortality. Induction immunosuppression at the time of transplant reduces the early risk and has additional benefits. The induction agent of choice within our program was changed from rabbit antithymocyte\u2010globulin (rATG) to basiliximab, so it was necessary to evaluate whether this had any impact on patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our primary objective was to describe rejection, infection, and other outcomes in adult heart transplant patients at the University of Alberta Hospital in Edmonton, Canada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a nonrandomized, retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010three patients were included with median ages 50 years versus 54 years. More female patients received rATG (20%\u00a0vs. 42.4%). The most common indication for transplant in both cohorts was ICM (63.3%\u00a0vs. 57.6%). Patients who received rATG had significantly higher PRA (0%\u00a0vs. 43%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Acute rejection episodes were similar between basiliximab and rATG at 3 months (16.7%\u00a0vs. 15.1%; <jats:italic>p<\/jats:italic>\u00a0=\u00a01.0) and 6\u2010months (30.0%\u00a0vs. 18.1%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.376). Infections were not statistically different with basiliximab compared to rATG at 3\u2010months, 43.3%\u00a0vs. 63.6% and at 6\u2010months 60.0%\u00a0vs. 66.7%). There were no fatalities in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study did not demonstrate differences in rejection with basiliximab compared to rATG. Mortality did not differ, but basiliximab\u2010treated patients had fewer infections and infection\u2010related hospitalizations than those treated with rATG. Larger studies with longer durations are needed to more completely describe the differences in rejection and infectious outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15332","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T11:54:03Z","timestamp":1716897243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of immunosuppression induction with basiliximab compared to antithymocyte\u2010globulin in adult heart transplant patients"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9716-3266","authenticated-orcid":false,"given":"Theresa E.","family":"Eberhardt","sequence":"first","affiliation":[{"name":"Pharmacy Services Alberta Health Services  Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta Division of Cardiology  Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Nethersole","sequence":"additional","affiliation":[{"name":"Transplant Services University of Alberta Hospital, Alberta Health Services  Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3281-7915","authenticated-orcid":false,"given":"Glen J.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta Division of Cardiology  Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.10.015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2016.11.034"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2007.00748.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.09.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.08.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.05.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.01.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13651"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14440"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13871"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.04.001"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.03.019"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000093"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008842.pub2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.09.002"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.09.043"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T05:13:48Z","timestamp":1719292428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/ctr.15332"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15332","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2024,5,28]]},"assertion":[{"value":"2024-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15332"}}